Results 71 to 80 of about 2,142,422 (318)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Quantization as a dimensional reduction phenomenon

open access: yes, 2006
Classical mechanics, in the operatorial formulation of Koopman and von Neumann, can be written also in a functional form. In this form two Grassmann partners of time make their natural appearance extending in this manner time to a three dimensional ...
Gozzi, E., Mauro, D.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Dimensional reduction and (Anti) de Sitter bounds

open access: yesJournal of High Energy Physics, 2021
Dimensional reduction has proven to be a surprisingly powerful tool for delineating the boundary between the string landscape and the swampland. Bounds from the Weak Gravity Conjecture and the Repulsive Force Conjecture, for instance, are exactly ...
Tom Rudelius
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Dimensional reduction of the generalized DBI

open access: yesNuclear Physics B, 2015
We study the generalized Dirac–Born–Infeld (DBI) action, which describes a q-brane ending on a p-brane with a (q+1)-form background. This action has the equivalent descriptions in commutative and non-commutative settings, which can be shown from the ...
Jun-Kai Ho, Chen-Te Ma
doaj   +1 more source

Dimensional reduction of higher derivative heterotic supergravity

open access: yesJournal of High Energy Physics, 2022
Higher derivative couplings of hypermultiplets to 6D, N = (1, 0) supergravity are obtained from dimensional reduction of 10D heterotic supergravity that includes order α′ higher derivative corrections.
Hao-Yuan Chang   +2 more
doaj   +1 more source

Regularization of supersymmetric theories - recent progress

open access: yes, 2006
General issues concerning the regularization of supersymmetric theories using dimensional regularization and dimensional reduction are reviewed. Recent progress on problems of dimensional reduction related to factorization, supersymmetry, Higgs boson ...
't Hooft   +30 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

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