Results 81 to 90 of about 2,133,508 (317)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Dimensional reduction in manifold-like causal sets

, 2017
We investigate the behavior of small subsets of causal sets that approximate Minkowski space in three, four, and five dimensions, and show that their effective dimension decreases smoothly at small distances.
Abajian, J., Carlip, S.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Informed dimension reduction of clinically-related genome-wide association summary data characterises cross-trait axes of genetic risk [PDF]

, 2020
Oliver S. Burren, Guillermo Reales, Limy Wong, John Bowes, James Lee, Anne Barton, Paul Lyons, Kenneth G. C. Smith, Wendy Thomson, Paul Kirk, Chris Wallace   +10 more
openalex   +1 more source

Parkinson’s Disease Diagnosis in Cepstral Domain Using MFCC and Dimensionality Reduction with SVM Classifier [PDF]

, 2021
Atiqur Rahman, Sanam Shahla Rizvi, Irfan Ullah Khan, Aaqif Afzaal Abbasi, Shafqat Ullah Khan, Tae‐Sun Chung   +5 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Quantization as a dimensional reduction phenomenon

, 2006
Classical mechanics, in the operatorial formulation of Koopman and von Neumann, can be written also in a functional form. In this form two Grassmann partners of time make their natural appearance extending in this manner time to a three dimensional ...
Gozzi, E., Mauro, D.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Reduction of infinite dimensional equations

Electronic Journal of Differential Equations, 2006
In this paper, we use the general Legendre transformation to show the infinite dimensional integrable equations can be reduced to a finite dimensional integrable Hamiltonian system on an invariant set under the flow of the integrable equations.
Zhongding Li, Taixi Xu
doaj  

Towards Synthetic Augmentation of Training Datasets Generated by Mobility-on-Demand Service Using Deep Variational Autoencoders

Applied Sciences
The machine learning-based approaches for analysing the mobility needs of users are currently the most prevalent approach in the mobility-on-demand (MoD) analysis.
Martin Gregurić, Filip Vrbanić, Edouard Ivanjko   +2 more
doaj   +1 more source