Results 101 to 110 of about 316,362 (306)

Reconceptualising ADHD as a neurobiological spectrum: calibration-based perspective

BJPsych Bulletin
Although attention-deficit hyperactivity disorder (ADHD) diagnosis requires a categorical decision, phenotypic, twin and molecular genetic evidence indicates that ADHD traits are continuously distributed, with clinical ADHD at the functionally impairing ...
Aslı Kazgan Kılıçaslan
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Metamaterials with high degrees of freedom: space, time, and more

Nanophotonics, 2020
In this brief opinionated article, I present a personal perspective on metamterials with high degrees of freedom and dimensionality and discuss their potential roles in enriching light–matter interaction in photonics and related fields.
Engheta Nader
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Avoiding the Curse of Dimensionality in Dynamic Stochastic Games [PDF]

Discrete-time stochastic games with a finite number of states have been widely ap- plied to study the strategic interactions among forward-looking players in dynamic en- vironments.
Kenneth L. Judd, Ulrich Doraszelski
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proximities in dimensionality reduction

, 2022
International audienceDimensionality reduction aims at representing high-dimensional data in a lower-dimensional representation, while preserving their structure (clusters, outliers, manifold).
Journaux, Ludovic, De Bodt, Cyril, Sautot, Lucile, Bodt De, Cyril, Lee, John Aldo   +4 more
core   +1 more source

Dimensionality Engineering of 1D, 2D, and 3D High‐Entropy Alloys for Advanced Electrocatalysis

Small Structures
High‐entropy alloys (HEAs) are emerging as promising candidates for advanced electrocatalysis due to their multi‐elemental compositions, tunable electronic structures, and remarkable stability. Recent advances in synthesis have enabled the fabrication of
Jing Yang, Deyang Xu, Peixin Zhang, Congxu Wang, Shuang Wang, Zhigang Hu, Tian Tian   +6 more
doaj   +1 more source

Environmental dimensionality.

Journal of theoretical biology, 2018
The number of regulating variables n in a given system is an upper bound to the number of coexisting species at equilibrium according to the competitive exclusion principle. However, it may be possible to formulate the model with a lower number of regulating variables, the smallest number of which is the dimension of the environmental feedback. Here we
Parvinen Kalle, Dieckmann Ulf
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source