Results 111 to 120 of about 63,869 (278)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Variable dimension automatic synthesis programs (VASP) [PDF]

, 1972
Variable dimension FORTRAN 4 version of the Automatic Synthesis Program (ASP) compensates for limitations within the program itself. Improvements are versatile programming language, convenient input/output format, new subprograms, variable dimensioning ...
Lee, H. Q., White, J. S.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Dimensioning of nursing professionals: implications for the work process in the family health strategy

Escola Anna Nery
Objective: To report the experience of the construction of nursing dimensioning and its implications for the working process in a Family Health Unit (FHU). Method: Descriptive report, which used the recommendations of Resolution No.
Lucas Cardoso dos Santos, Juliane Andrade, Wilza Carla Spiri   +2 more
doaj   +1 more source

Reduced scale feasibility of temperature rise tests in substation connectors [PDF]

, 2016
Due to the important increase of the power of electrical transmission and distribution grids expected for the following years, especially in developing countries such as Kenya, Brazil, Philippines or Mexico among others, that have planes of generating ...
Abomailek Rubio, Basel Carlos, Casals Torrens, Pau, Riba Ruiz, Jordi-Roger   +2 more
core  

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Finitistic dimension and restricted flat dimension

Journal of Algebra, 2008
The main result of this paper is the following statement: Theorem. Let \(R\) be a ring and \(T\) an \(R\)-module. Denote \(A=\text{End}_R(T)\). (1) If \(T\) is selfsmall and coproduct-selforthogonal in the category of all \(R\)-modules, then the restricted flat dimension of \(T_A\) does not exceed the finitistic dimension of \(_AA\), which, in turn, is
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Strut-tie method of design and possible serviceability problems: an exploration by NLFE [PDF]

, 2000
The strut and tie method presents a rational and consistent approach to the design of all parts in a reinforced concrete structure. With this approach, the load carrying mechanism of the structure is represented by approximating the compressive stress
Bhatt, P., Cunningham, L.S.
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source