Results 91 to 100 of about 63,869 (278)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Irrigation dimensioning of reel machines with water distribution systems: gun and boom with emitters

Cuadernos del CURIHAM, 2020
The reel machines irrigation technique has expanded in recent years thanks to the technological improvements that have been introduced. Several investigations have been carried out regarding the effectiveness of the irrigation of this equipment with “gun”
Esequiel Rolando Jiménez Espinosa
doaj   +1 more source

Point Pollution Sources Dimensioning [PDF]

In this paper a method for determining the main physical characteristics of the point pollution sources is presented. It can be used to find the main physical characteristics of them.
Georgeta CUCULEANU
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Advanced Optimization Models for Bandwidth Provisioning and Routing in Fixed Microwave Backhaul Networks

Transport and Telecommunication
This paper addresses the problem of determining bandwidth allocation and traffic routes in fixed microwave networks such that overall bandwidth cost is minimized while traffic demands are satisfied with a required reliability level.
Mehadji Djamil Abdelhak, Kaddour Mejdi
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Magnetic and Thermal Behavior of a Planar Toroidal Transformer

Energies
This paper presents a study on the magnetic and thermal behaviors of a planar toroidal transformer, comprising two planar toroidal coils. In our configuration, the primary coil consists of twenty turns, while the secondary coil consists of ten turns ...
Kahina Benamer, Azzedine Hamid, Eugenia Rossi di Schio, Abderrahim Mokhefi, Rabia Melati, Paolo Valdiserri   +5 more
doaj   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Updating the Design Map of Frost Indexes as a Prerequisite for Relevant Assessment of Track Substructure for Non-Traffic Load

Civil and Environmental Engineering, 2018
The initial part of the paper briefly characterizes the present state of the track substructure dimensioning for the non-traffic load and the necessity of updating the design map of frost indexes IFd as a basis for dimensioning. A substantial part of the
Ižvolt Libor, Dobeš Peter, Pieš Juraj
doaj   +1 more source