Results 261 to 270 of about 679,917 (339)

Insights into the structural differences between homo- and heterodimers enriched from a cocktail of monoclonal antibodies against SARS-CoV-2. [PDF]

Sci Rep
Nguyen JB, Liu S, Yan Y, Choudhary D, Oberholtzer ZR, Zhou Y, Skow DJ, Sheikh M, Sandu C, Wang S, Li N, Franklin MC, Rosconi MP, Pyles EA.   +13 more
europepmc   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

d-Dimer With the Aortic Dissection Detection Risk Score May Improve Patient Selection for Acute Aortic Syndrome Diagnostic Imaging. [PDF]

Emerg Med Australas
Bhat S, Bhat S, Schreve F, Bergin CJ, Jones PG, Waqanivavalagi SWFR.   +5 more
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Molecular structure and nickel-binding capacity of Proteus mirabilis UreE. [PDF]

Acta Crystallogr D Struct Biol
Pan J, Mueller SL, Tasneem N, Wu Y, Furlong EJ.   +4 more
europepmc   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Additional file 1 of Pre-CT risk stratification using the D-dimer/pCO₂ ratio in D-dimer–positive emergency department patients: diagnostic accuracy study

Yıldırım, Cem, Aykut, Ahmet, Günsoy, Ertuğ, Öncül, Mehmet Veysel   +3 more
openalex   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Cavitand-Mediated Photodimerization of Chalcones: The Effect of Supramolecular Influences and Temperature on Reaction Selectivity. [PDF]

Molecules
Chatterjee J, Pattabiraman M, Chakraborty D, Wysocki AL, Kovacs F.   +4 more
europepmc   +1 more source

Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis.

Grégoire Le Gal, Helia Robert-Ebadi, Venkatesh Thiruganasambandamoorthy, Farés Moustafa, Andréa Penaloza, Judith Catella, Marie Chevallier Grenot, Shaun Visser, Lucia Mazzolai, Alain Plumacker, Stefano Barco, Eddy Lang, Vicky Tagalakis, Claire Déroche, Meghan Garnett, Jennifer Hulme, Pierre-Marie Roy, Alexandre Ghuysen, Francis Couturaud, Rolf P. Engelberger, Dominique El Kouri, Drahomir Aujesky, Marc Righini   +22 more
openalex   +1 more source