Results 291 to 300 of about 679,917 (339)
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Current Medicinal Chemistry, 2022
Abstract: This review intends to summarize the structures of an extensive number of symmetrical-dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility of biologically active substances reported to possess dimeric structures.
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Abstract: This review intends to summarize the structures of an extensive number of symmetrical-dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility of biologically active substances reported to possess dimeric structures.
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Chemistry – A European Journal, 2019
AbstractBinaphthyl‐3,3′,4,4′‐tetraone was prepared and coupled to different bis(TIPS‐ethynyl)‐substituted (TIPS=triisopropyl silane) aromatic diamines, resulting in the formation of dimeric benzo‐fused azaacenes, centrally connected by a single bond.
Sebastian Hahn +9 more
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AbstractBinaphthyl‐3,3′,4,4′‐tetraone was prepared and coupled to different bis(TIPS‐ethynyl)‐substituted (TIPS=triisopropyl silane) aromatic diamines, resulting in the formation of dimeric benzo‐fused azaacenes, centrally connected by a single bond.
Sebastian Hahn +9 more
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Modelling dimer–dimer reactions on supported catalysts
Journal of Mathematical Chemistry, 2014zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Skakauskas, V., Katauskis, P.
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2016
It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents.
Shang-Gao, Liao, Jian-Min, Yue
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It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents.
Shang-Gao, Liao, Jian-Min, Yue
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Angewandte Chemie, 2023
AbstractPolycyclic hydrocarbons consisting of two or more directly fused antiaromatic subunits are rare due to their high reactivity. However, it is important to understand how the interactions between the antiaromatic subunits influence the electronic properties of the fused structure.
Tingting Xu +5 more
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AbstractPolycyclic hydrocarbons consisting of two or more directly fused antiaromatic subunits are rare due to their high reactivity. However, it is important to understand how the interactions between the antiaromatic subunits influence the electronic properties of the fused structure.
Tingting Xu +5 more
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Journal of the American Chemical Society, 2012
We suggest four new benzene dimers, (C(6)H(6))(2), all featuring one or more cyclohexadiene rings trans-fused to 4- or 6-membered rings. These hypothetical dimers are 50-99 kcal/mol less stable than two benzenes, but have computed activation energies to fragmentation ≥27 kcal/mol.
Andrey Yu, Rogachev +2 more
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We suggest four new benzene dimers, (C(6)H(6))(2), all featuring one or more cyclohexadiene rings trans-fused to 4- or 6-membered rings. These hypothetical dimers are 50-99 kcal/mol less stable than two benzenes, but have computed activation energies to fragmentation ≥27 kcal/mol.
Andrey Yu, Rogachev +2 more
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Soft Matter, 2014
We report the synthesis and properties of a dibenzophenazine discotic dimer, which was found to adopt a folded conformation in solution. This stable π-stacked structure persists at elevated temperatures and in all solvents examined. Folding allows the dimer to assemble into a columnar liquid crystal phase, despite its short linking group.
Kevin J A, Bozek, Vance E, Williams
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We report the synthesis and properties of a dibenzophenazine discotic dimer, which was found to adopt a folded conformation in solution. This stable π-stacked structure persists at elevated temperatures and in all solvents examined. Folding allows the dimer to assemble into a columnar liquid crystal phase, despite its short linking group.
Kevin J A, Bozek, Vance E, Williams
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Journal of Molecular Spectroscopy, 1999
Spectra of the symmetric nu1 vibration of the NO dimer have been recorded in gas phase at low temperature, with a high-resolution infrared Fourier transform spectrometer. All the lines were least-squares fitted to a Voigt profile convoluted with the well-known apparatus function of the spectrometer. By means of this method, the frequencies of more than
, Dkhissi, , Lacome, , Perrin
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Spectra of the symmetric nu1 vibration of the NO dimer have been recorded in gas phase at low temperature, with a high-resolution infrared Fourier transform spectrometer. All the lines were least-squares fitted to a Voigt profile convoluted with the well-known apparatus function of the spectrometer. By means of this method, the frequencies of more than
, Dkhissi, , Lacome, , Perrin
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2012
The specific self-association of proteins to form homodimers and higher order oligomers is an extremely common event in biological systems. In this chapter we review the prevalence of protein oligomerization and discuss the likely origins of this phenomenon.
Jacqueline M, Matthews, Margaret, Sunde
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The specific self-association of proteins to form homodimers and higher order oligomers is an extremely common event in biological systems. In this chapter we review the prevalence of protein oligomerization and discuss the likely origins of this phenomenon.
Jacqueline M, Matthews, Margaret, Sunde
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2008
Tropomyosins consist of nearly 100% alpha-helix and assemble into paralleldimeric coiled-coils. Nonmusde as well as muscle tropomyosins can form homodimers, however, expression of both muscle alpha and beta tropomyosin subunits results in the preferential formation of stable alpha/beta heterodimers in native muscle.
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Tropomyosins consist of nearly 100% alpha-helix and assemble into paralleldimeric coiled-coils. Nonmusde as well as muscle tropomyosins can form homodimers, however, expression of both muscle alpha and beta tropomyosin subunits results in the preferential formation of stable alpha/beta heterodimers in native muscle.
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