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British anti-Lewisite (dimercaprol): An amazing history
Annals of Emergency Medicine, 2003Emergency physicians are familiar with British anti-Lewisite (BAL) because it is a heavy metal-chelating agent that is recommended in some cases of metal poisoning, especially arsenic. Although there are more modern chelating agents, the fact that BAL is still recommended and stocked by hospital pharmacies more than 60 years after its initial synthesis
Joel A, Vilensky, Kent, Redman
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Acute systemic toxicity of pure dimercaprol and trimercaptopropane
Toxicology and Applied Pharmacology, 1976Abstract Dimercaprol, free of 1,2,3-trimercaptopropane (TMP), TMP, and mixtures of these two compounds were injected intramuscularly and intraperitoneally into fasted rats and mice, respectively. The LD50 values for dimercaprol and TMP in rats were 87 and 19 mg/kg. The corresponding LD50 values in mice were 90 and 20 mg/kg.
P, Zvirblis, R I, Ellin
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Effect of dimercaprol on oxygen toxicity in rats
Journal of Applied Physiology, 1965Six groups of 10 male Holtzman rats were given doses of 10, 25, 40, 50, 75, and 100 mg/kg dimercaprol, respectively. Both times of onset of the first convulsion and survival times of treated animals exposed to 6 atm of oxygen were measured and compared with 50 untreated controls. As the dose of dimercaprol increased to 40 mg/kg, both the time of onset
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