Results 1 to 10 of about 335 (60)
Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022 Fungal infections, including those caused by Candida spp., are recognized in immunocompromised individuals for their high rates of morbidity and mortality. Microorganism resistance to conventional drugs compromises treatment effectiveness and yet also reveals the need to develop new drugs.
Allana B. S. Duarte +5 more
wiley +1 more source
Molecular underpinnings of methyl jasmonate‐induced resistance in Norway spruce
Plant, Cell &Environment, Volume 43, Issue 8, Page 1827-1843, August 2020., 2020 Abstract In response to various stimuli, plants acquire resistance against pests and/or pathogens. Such acquired or induced resistance allows plants to rapidly adapt to their environment. Spraying the bark of mature Norway spruce (Picea abies) trees with the phytohormone methyl jasmonate (MeJA) enhances resistance to tree‐killing bark beetles and their
Melissa H. Mageroy +9 more
wiley +1 more source
Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis [PDF]
, 2008 Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK ...
Dong, Aiping +28 more
core +1 more source
Advances in Bioinformatics, Volume 2011, Issue 1, 2011., 2011 Various enzyme identification protocols involving homology transfer by sequence‐sequence or profile‐sequence comparisons have been devised which utilise Swiss‐Prot sequences associated with EC numbers as the training set. A profile HMM constructed for a particular EC number might select sequences which perform a different enzymatic function due to the ...
Dhwani K. Desai +4 more
wiley +1 more source
International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011 Classical population genetics shows that varying permutations of genes and risk factors permit or disallow the effects of causative agents, depending on circumstance. For example, genes and environment determine whether a fox kills black or white rabbits on snow or black ash covered islands.
C. J. Carter, A. Conti
wiley +1 more source
Putative unigenes related to the biosynthesis of hyperforin, hypericin, and melatonin.
, 2012 NU, number of unigenes; MNCG, maximum number of coding genes. MAT, dimethylallyltranstransferase; Hyp-1, Hypericum perforatum phenolic oxidative coupling protein; MAT, dimethylallyltranstransferase; DXS, 1-D-deoxyxylulose 5-phosphate synthase; DXR, 1 ...
Miao He (148269) +4 more
core +1 more source
, 2012 Dashed box within (B) occurs in animals. Hyp-1, Hypericum perforatum phenolic oxidative coupling protein; MEP pathway, non-mevalonate pathway; MAT, dimethylallyltranstransferase; AS I, anthranilate synthase I; AS II, anthranilate synthase II; PAT ...
Miao He (148269) +4 more
core +1 more source
Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
, 1999 Bisphosphonates (Bps), inhibitors of osteoclastic bone resorption, are used in the treatment of skeletal disorders. Recent evidence indicated that farnesyl pyrophosphate (FPP) synthase and/or isopentenyl pyrophosphate (IPP) isomerase is the intracellular
Löwik, C. +4 more
core