Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease [PDF]
, 2012 Background Systems biology holds promise as a new approach to drug target identification and drug discovery against neglected tropical diseases. Genome-scale metabolic reconstructions, assembled from annotated genomes and a vast array of bioinformatics ...
Blazier, Anna S +5 more
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Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes [PDF]
, 2018 The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are ...
Athanasiou, Ioannis +13 more
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Phlebia radiata as an ethanol producing fungus : conversion of lignocelluloses and metabolic regulation under hypoxia [PDF]
, 2020 White rot Basidiomycota can decompose all wood components in nature and are therefore essential in recycling carbon in our forests and ecosystems. These fungi are filamentous organisms that reside on top of trunks and elongate their hyphae inside wood ...
Mattila, Hans
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Mutation Rate and Gene Expression in Genetic Admixtures of Domesticated Citrus [PDF]
, 2023 Tesis por compendio[ES] La domesticación de los cítricos es un proceso en gran parte desconocido. Las investigaciones llevadas a cabo hasta la fecha indican que las variedades de cítricos que se comercializan en la actualidad son, en general, el producto
Pérez Román, Estela
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Biomarker discovery for asthma phenotyping: From gene expression to the clinic [PDF]
, 2016 Asthma is considered a complex respiratory disease of which various asthma phenotypes are being discovered. Clinical biomarkers have shown to be successful in the management of asthma phenotypes.
Wagener, A.H.
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Impact of biospecimens handling on biomarker research in breast cancer [PDF]
, 2009 Background Gene expression profiling is moving from the research setting to the practical clinical use. Gene signatures able to correctly identify high risk breast cancer patients as well as to predict response to treatment are currently under intense ...
Loris De Cecco +8 more
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The Genome Scale Metabolic Model of Cryptosporidium hominis: iNV209 [PDF]
, 2009 The apicomplexan Cryptosporidium is a protozoan parasite of humans and other mammals. Cryptosporidium species cause acute gastro-enteritis and diarrheal disease in healthy humans and animals, and cause life-threatening infection in immuno-compromised ...
Vanee, Niti
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Comparative analysis of sterol acquisition in the oomycetes Saprolegnia parasitica and Phytophthora infestans [PDF]
, 2017 The oomycete class includes pathogens of animals and plants which are responsible for some of the most significant global losses in agriculture and aquaculture.
Bulone, V. +4 more
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Plant Phytochrome Signaling in an Evolutionary Context [PDF]
, 2015 This work investigated the evolution of phytochrome signaling and reponses in land plants. Phytochromes and phytochrome signaling components from non-seed plants, such as the moss Physcomitrella patens, were characterized in their functional properties ...
Possart, Anja Simone
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Pathological Studies on Histogenesis of Stem Cell-Derived Rat Tumors, with Particular References to Cellular Properties of Malignant Fibrous Histiocytoma and Malignant Teratoma [PDF]
, 2016 Osaka Prefecture University (大阪府立大学)博士（獣医学）application/pdfThesis学位記番号：論獣第205号, 指導教員：山手 丈至doctoral ...
小寺, 喬
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