Results 11 to 20 of about 454 (180)

Formation of NDMA by chloramination of nitrogenous pharmaceuticals [PDF]

, 2010
International audienceMany disinfection by-products (DBPs) are formed during water chlorination, including trihalomethanes (THMs) and haloacetic acids (HAAs). Disinfection with chloramines is often used to reduce the production of regulated DBPs. However,
Gallard, Hervé, Le Roux, Julien, Croué, Jean-Philippe   +2 more
core   +7 more sources

Complex Self-Organization in <i>n</i>-Alkylammonium Sulfobetaine Zwitterions with High Thermal Stabilities and High Expansion Coefficients. [PDF]

Langmuir
Sulfobetaine zwitterions made from n-alkyl dimethylamines and butanesultone yield a series of n-alkylammonium sulfobetaine zwitterions with complex self-organization behavior.
Lange A, Holtzheimer L, Clarke C, Thünemann AF, Taubert A.   +4 more
europepmc   +2 more sources

Synthesis of Aminocyclopropanes by Redox-Neutral Aminoalkylation. [PDF]

Angew Chem Int Ed Engl
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Oliver GA, Günther K, Sebastianelli-Schoditsch C, Woolford S, Ludwig I, Sitte HH, Maulide N.   +6 more
europepmc   +2 more sources

A Role for Janus Cyclohexyl Ring Motifs in Medicinal Chemistry. Incorporation Into G-Quadruplex Ligands and Anti-Trypanosoma brucei Activity. [PDF]

Chembiochem
Naphthalene diimide (NDI) cores with peripheral fluorocyclohexyl ring systems are explored binding to G‐quadruplex DNA and were also assayed against the Trypanosoma brucei parasite. The most active compound of the series displayed nanomolar activity and suggested electrostatic interactions between the polarized cyclohexane and G‐Quad DNA.
Stewart JM, Kehler M, Kuodis V, Parkinson GN, Chen W, Smith TK, Waller ZAE, O'Hagan D.   +7 more
europepmc   +2 more sources

Phosphorus(V) Complexes with Acyclic Monoaminocarbene Ligands via Oxidative Addition

, 2016
(Difluoroorganyl)­dimethylamines, RCF2NMe2 (R = H, Ph, tBu), can be used as carbene precursors for phosphorus trifluoride in an oxidative addition reaction.
Lyuben Zhechkov (1565404), Bassem S. Bassil (1290633), Tobias Böttcher (1957576), Gerd-Volker Röschenthaler (1957573)   +3 more
core   +4 more sources

A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K⁺ Channel in Breast Cancer. [PDF]

Cancers (Basel), 2022
Since the multifunctionality of transglutaminase 2 (TG2) includes extra- and intracellular functions, we investigated the effects of intracellular administration of TG2 inhibitors in three breast cancer cell lines, MDA-MB-231, MDA-MB-436 and MDA-MB-468 ...
Canella R, Brugnoli F, Gallo M, Keillor JW, Terrazzan A, Ferrari E, Grassilli S, Gates EWJ, Volinia S, Bertagnolo V, Bianchi N, Bergamini CM.   +11 more
europepmc   +2 more sources

A Copper-Catalyzed Synthesis of 3‑Aroylindoles via a sp³ C–H Bond Activation Followed by C–C and C–O Bond Formation

, 2016
An efficient Cu(I)-catalyzed synthesis of 3-aroylindoles has been achieved from o-alkynylated N,N-dimethylamines via a sp3 C–H bond activation α to the nitrogen atom followed by an intramolecular nucleophilic attack with the alkyne using an aqueous ...
Anupal Gogoi (1528207), Bhisma K. Patel (1479115), Saroj Kumar Rout (1923505), Srimanta Guin (1528210)   +3 more
core   +2 more sources

Efficient, Green, and Renewable N-Di-Methylation Synthesis of Amines by a Novel Nano-Catalyst of NiNiO@C [PDF]

, 2021
The development of Earth-abundant reusable and no-toxic heterogeneous catalyst applied in the pharmaceutically, bio-active relevant compounds synthesis as well as other organic syntheses still remains as the most important goal of the general chemical ...
Jianguo, Liu, Longlong, Ma, Mingyue, Zhang, Yanpei, Song, Xiuzheng, Zhuang   +4 more
core   +1 more source

Structure‐Property Relationships in Catecholamine Coatings for Broad Surface Functionalization

Advanced Functional Materials, EarlyView.
Inspired by mussel adhesive proteins (MAPs), six catecholamine molecules with different molecular structure were systematically characterized and compared based on their ability to form homogeneous, reactive coatings. Highlighting candidates capable of balancing coating properties of interest, their successful use as primer layers for organic and ...
Caroline F. Harms, Qiming Li, Ye‐Sol Kim, Anish Tuteja, Jinsang Kim, Abdon Pena‐Francesch   +5 more
wiley   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source