Results 111 to 120 of about 11,028,576 (294)
Advanced Science, EarlyView.Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang +9 more
wiley +1 more source
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Advanced Science, EarlyView.The d‐band center and bifunctional mechanism jointly regulate the amounts of adsorbed OH* and CO*, thereby enhancing electrocatalytic performance, while the application of an external magnetic field further boosts this performance. ABSTRACT The spin‐dependent electronic structure of transition‐metal alloys plays a key role in tuning the magnetic‐field ...
Qiqi Mo +6 more
wiley +1 more source
Advanced Science, EarlyView.Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong +7 more
wiley +1 more source
, 2015 A visible light communication system with simultaneous brightness control and data transmission is experimentally demonstrated in this paper. A pulse-width modulation (PWM) scheme is adopted for brightness control of the light-emitting diode and pulse ...
Choi, Joon-Ho +4 more
core +1 more source
IEEE AccessThis paper presents a proof of concept intelligent lighting system designed to reduce energy consumption while delivering the target photosynthetic photon flux density (PPFD) at the plant canopy level, a key factor in optimizing plant growth.
Valeria Solano +2 more
doaj +1 more source
Physics‐Guided Multi‐Channel Restoration for Efficient and Accurate Atomic Force Microscopy Imaging
Advanced Science, EarlyView.Schematic figure of restoring noisy atomic force micrscopy (AFM) image via physics‐guided multi‐channel restoration. The lighter neural network models with multiple‐channel input from auxiliary signals outperforms heavier model with single‐channel input.
Jaeuk Sung +13 more
wiley +1 more source
Research Data: Unary-Coded Dimming Control Improves ON-OFF Keying Visible Light Communication
An ideal Visible Light Communication (VLC) system should facilitate reliable data transmission at high throughputs, while also providing flicker-free illumination at the user-defined dimming level.
Maunder, Robert +8 more
core +1 more source
A Dual-Threshold Strategy for Maximizing Power Efficiency in Head-Mounted Displays
IEEE AccessThis study proposes and validates a dual-threshold strategy for foveated brightness control (FBC), which maximizes power efficiency in virtual reality (VR) displays.
Won-Been Jeong +5 more
doaj +1 more source
Development of Versatile Nanoparticle System for Efficient Drug Delivery into Pulmonary Endothelium
Advanced Science, EarlyView.Pediatric acute respiratory distress syndrome (PARDS) suppresses the FOXF1 transcription factor and disrupts lung development. This study shows that the FOXF1‐activating small‐molecule compound, TanFe[F], can be precisely delivered to lung endothelial cells using the innovative LEDD nanoparticle system.
Afzaal N. Mohammed +12 more
wiley +1 more source