Results 41 to 50 of about 301,649 (230)

Re‐evaluating variability of circulating miR‐122 in healthy volunteers: Implications for biomarker qualification in drug‐induced liver injury

British Journal of Clinical Pharmacology, EarlyView.
Drug‐induced liver injury (DILI) remains a major challenge in clinical practice and drug development, and reliable biomarkers are still needed. MicroRNA‐122 (miR‐122) has shown promise, but reported inter‐individual variability in healthy populations has raised concerns about its clinical utility.
Irum Javid, Giusy Russomanno, Anthony Evans, Guruprasad P. Aithal, Shiva S. Forootan, Warren E. Glaab, Matthias Hackl, Joely Irlam, Kseniya Khamina‐Kotisch, Samantha Korver, Gerd A. Kullak‐Ublick, Sophia L. Samodelov, Christopher E. Goldring   +12 more
wiley   +1 more source

İlahiyat Öğrencilerinin Arapça Dersine Yönelik Tutumlarının Akademik Başarıya Etkisi

Marife Dini Araştırmalar Dergisi, 2022
İnsan, sosyal bir varlık olması sebebiyle başta diğer insanlar olmak üzere çevresindeki canlılarla iletişim kurma ihtiyacı ile doğar. İnsanlık tarihinin değişmez olgusu olan dil ise iletişimin en önemli unsurlarındandır.
Halime Çoban
doaj   +1 more source

DİN DİLİ DİNÎ DİL AYRIMI

Gaziosmanpasa Universitesi Sosyal Bilimler Arastirmalari Dergisi, 2016
Transmitted to humans through the prophets, containing the orders and prohibitions of God, and the revelation that covers all aspects of human life is a divine qualities carry this language sanctify the most basic features. This process amongst God, Prophet and human, but is substantially unidirectional illustrates a communication form.
openaire   +3 more sources

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Bir Din Eğitimi Materyali Olarak Çocuk İncilleri

Marife Dini Araştırmalar Dergisi, 2014
Dünya üzerindeki tüm dinler ilâhi öğretilerini kutsal metinlere dayandırmaktadır. İnsanın mensup olduğu dine ait temel kanunları, hüküm ve yargıları uygun biçimde benimseyip uygulamaya aktarması ancak bu metinleri doğru anlayabilmesiyle müm-kündür. Bunun
Sümeyra Bilecik
doaj   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Din Eğitimi Ekseninde Türkiye’de Medya ve Din Araştırmaları [PDF]

, 2019
Kitle iletişim araçları, ya da daha yaygın kullanımlarıyla medya ile din alanı arasındaki ilişki, 2000’li yıllardan itibaren Türk akademisinin temel araştırma konularından bir tanesi haline gelmiştir.
Ayşe Zişan Furat, Furat, Ayşe Zişan
core   +1 more source

Süryaniler, Kimlik, Din, Literatür

, 2023
Bu editöryal çalışma, Süryanilerde kimlik, algısı, din araştırmaları ve literatür incelemelerini ...
Var, Umut
core