Results 211 to 220 of about 136,601 (306)

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

Prenatal exposure to paracetamol and the risk of autism and attention‐deficit/hyperactivity disorder: An umbrella review and meta‐meta‐analysis

Developmental Medicine &Child Neurology, EarlyView.
This meta‐meta‐analysis synthesizes evidence on prenatal paracetamol exposure and neurodevelopmental outcomes. Crude analyses suggest small associations with autism and ADHD, but these attenuate substantially when restricting to high‐quality meta‐analyses and low‐bias primary studies.
Hoda Tayebi‐Hillali, María Blanco‐Suárez, Berta Rivas‐Mundiña, Jacobo Limeres‐Posse, Márcio Diniz‐Freitas, Pedro Diz‐Dios   +5 more
wiley   +1 more source

Obesity and Iron Metabolism: Mechanisms, Status Assessment, and Clinical Implications. [PDF]

Curr Obes Rep
Aguree S, Meng X.
europepmc   +1 more source

¿Aumenta la exposición prenatal al paracetamol el riesgo de trastorno del espectro autista y trastorno por déficit de atención con hiperactividad? Una revisión paraguas y un meta‐meta‐análisis

Developmental Medicine &Child Neurology, EarlyView.
Este meta‐metaanálisis sintetiza la evidencia disponible sobre la exposición prenatal al paracetamol y los desenlaces del neurodesarrollo. Los análisis crudos sugieren pequeñas asociaciones con el trastorno del espectro autista (TEA) y el trastorno por déficit de atención e hiperactividad (TDAH); sin embargo, estas asociaciones se atenúan de forma ...
Hoda Tayebi‐Hillali, María Blanco‐Suárez, Berta Rivas‐Mundiña, Jacobo Limeres‐Posse, Márcio Diniz‐Freitas, Pedro Diz‐Dios   +5 more
wiley   +1 more source

Management of Chronic Non-Cancer Pain Through a Multicomponent Workshop Based on Non-Pharmacological Therapies: A Protocol for a Mixed-Methods Study, Including a Two-Arm Parallel-Group Randomized Clinical Trial and a Qualitative Component. [PDF]

Healthcare (Basel)
Ruiz-Romero MV, Garrido-Alfaro RA, Arroyo-Rodríguez A, Martínez-Monrobé MB, Pereira-Delgado C, López-Tarrida ÁC, Luciano JV, López-Millán JM, Moro-Muñoz S, Guerra-Martín MD, Pérez-García P, Gómez-Hernández MB.   +11 more
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Political determinants of cervical cancer control in Peru. [PDF]

BMC Health Serv Res
Gianella C, Salmon-Mulanovich G, Bohorquez-Gutierrez J, Tapia P, Perez-Buitrago SM.   +4 more
europepmc   +1 more source

Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background The role of amylin signalling in energy balance control has been understudied in calcitonin receptor (CTR) expressing nuclei such as the mesopontine laterodorsal tegmental nucleus (LDTg). Our lab has shown that LDTg amylin signalling reduces feeding and body weight, but the neuronal phenotype and downstream targets of LDTgCTR cells ...
Marcos J. Sanchez Navarro, Carlie Zhang, Samantha M. Fortin, Matthew R. Hayes   +3 more
wiley   +1 more source

Vocational rehabilitation for people with multiple sclerosis: A systematic scoping review of international evidence. [PDF]

PLoS One
Gualco C, Grange E, Rotondi F, Salivetto M, Pignattelli E, Manacorda T, Grasso MG, Presicce G, Inglese M, Nasone L, Durando P, Dini G, Persechino B, Brichetto G, Ponzio M.   +14 more
europepmc   +1 more source