Results 81 to 90 of about 136,601 (306)

NOTI Minuto - noviembre 2022

, 2022
El boletín NOTI Minuto es una publicación digital de acceso abierto, publicado mensualmente en versión electrónica por la Organización El Minuto de ...
Organización El Minuto de Dios
core  

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Análisis de la carga fiscal asociada al impuesto de renta sobre asalariados en Colombia, 1989 a 2018

Contaduría Universidad de Antioquia, 2019
Con el Decreto 649 de 1989 se establece el Estatuto Tributario Nacional, desde entonces al 2018 se implementaron quince reformas tributarias, modificando las condiciones de depuración de la base gravable para la determinación del impuesto de renta, esto ...
Juliana Carolina Farfán-Rodríguez, Maribel Duque-Correa, María del-Socorro Orrego-Cárdenas, Sandra Milena Sossa-Uribe   +3 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Insectos asociados entre un cultivo de Curuba y un fragmento de bosque alto andino de la Sabana de Bogotá

Inventum Ingeniería, Tecnología e Investigación, 2014
En el municipio de Madrid (Cundinamarca) se estableció un cultivo ecológico de curuba cerca de un Bosque Alto Andino y se realizaron muestreos semanales en bosque y cultivo para determinar los insectos asociados de importancia agroecológica.
Daniela Espejo González, Jonhy Hidalgo Martin, Maikol Santamaría Galindo, Johanna Fernandez   +3 more
doaj   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Diosmetin alleviates AFB1-induced endoplasmic reticulum stress, autophagy, and apoptosis via PI3K/AKT pathway in mice

Ecotoxicology and Environmental Safety
Aflatoxin B1 (AFB1), a prevalent agricultural mycotoxin, represents a serious health hazard to humans and animals owing to its toxic effects. Diosmetin (DIOS), a naturally occurring flavonoid, has demonstrated potential hepatoprotective properties.
Zhenlin Li, Mengjie Liu, Jie Li, Guorong Yan, Xiaoxiang Xu   +4 more
doaj   +1 more source

Rendimiento de lechuga Lactuca sativa L. variedad Arizona bajo riego y cobertura vegetal en el Ceagro San Pablo, Madrid (Cundinamarca)

Inventum Ingeniería, Tecnología e Investigación, 2012
En el Centro Agroecológico de Investigación y Capacitación Ceagro San Pablo, ubicado en el municipio de Madrid, Cundinamarca, se evaluó el rendimiento de la lechuga variedad Arizona, en suelos con y sin cobertura vegetal, riego por aspersión y por goteo,
Lady Carolina Sierra Buitrago, Sara Elizabeth Rodríguez Puentes, Mario de Jesús Molano Cogua, Maicol Santamaría Galindo   +3 more
doaj   +1 more source

El Minuto de Dios, una mirada desde las ciencias sociales [PDF]

, 2015
To understand the concept of Social Change by Rafael García Herreros, carried out in the social work at El Minuto de Dios, founded in 1957, it is made a look from the contemporary social sciences, aided with some theoretical approaches of Talcott Parsons,
Luis Guillermo Rubiano, Schuster Rodríguez, Hans, Rubiano, Luis Guillermo, Hans Schuster Rodríguez   +3 more
core   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source