Dipeptidase-1–knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer [PDF]
JCI InsightDipeptidase-1 (DPEP1) is highly upregulated in colorectal cancer (CRC), with its enzymatic function linked to invasion and metastasis. More recently, DPEP1 was found to serve as a receptor for neutrophils when expressed by activated endothelial cells. It
Sarah E. Glass +23 more
doaj +3 more sources
Probing the Reaction Mechanism of the D-ala-D-ala Dipeptidase, VanX, by Using Stopped-Flow Kinetic and Rapid-Freeze Quench EPR Studies on the Co(II)-Substituted Enzyme [PDF]
, 2006 In an effort to probe the reaction mechanism of VanX, the D-ala-D-ala dipeptidase required for high-level vancomycin resistance in bacteria, stopped-flow kinetic and rapid-freeze quench EPR studies were conducted on the Co(II)-substituted enzyme when ...
Bennett, Brian +5 more
core +4 more sources
Carnosine Dipeptidase(Cndp): An emerging therapeutic target for metabolic diseases and cancers [PDF]
Genes and DiseasesMetabolic diseases, associated with high morbidity and mortality rates, pose a challenge to global public health and a significant burden on society.
Liang Zhou +4 more
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Identification of KKL-35 as a Novel Carnosine Dipeptidase 2 (CNDP2) Inhibitor by In Silico Screening [PDF]
MoleculesExtracellular glutathione (GSH) is degraded on the cell surface, in which the γ-glutamyl residue is removed to generate cysteine–glycine (Cys–Gly) dipeptides that are subsequently transported to the cytoplasm.
Takujiro Homma +2 more
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A Novel Regulator PepR Regulates the Expression of Dipeptidase Gene pepV in Bacillus thuringiensis [PDF]
MicroorganismsBacillus thuringiensis produces insecticidal crystal proteins encoded by cry or cyt genes and targets a variety of insect pests. We previously found that a strong promoter of a DeoR family transcriptional regulator (HD73_5014) can efficiently drive ...
Xin Zhang +5 more
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Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease [PDF]
, 2000 Background: Cathepsin X is a widespread, abundantly expressed papain-like mammalian lysosomal cysteine protease. It exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity and shares a similar activity profile with cathepsin B.
Carmona, Adriana Karaoglanovic +6 more
core +4 more sources
Comprehensive pan-cancer investigation of carnosine dipeptidase 1 and its prospective prognostic significance in hepatocellular carcinoma [PDF]
Open MedicineCarnosine dipeptidase 1 (CNDP1), an enzyme integral to the hydrolysis of dipeptides containing histidine, plays an indispensable role in myriad physiological processes, including hydrolysis of proteins, maturation of specific biochemical functionalities ...
Huang Xiao-Wen +12 more
doaj +2 more sources
Functional Characterization of Different Fructilactobacillus sanfranciscensis Strains Isolated from Chinese Traditional Sourdoughs [PDF]
FoodsFructilactobacillus sanfranciscensis, the dominant species of lactic acid bacteria in sourdoughs, impacts the microstructure and flavor of steamed bread through exopolysaccharide production, acidification, proteolysis, and volatile compound generation ...
Huanyi Yang +7 more
doaj +2 more sources
Dipeptidase 1 is a functional receptor for a porcine coronavirus. [PDF]
Nat MicrobiolDufloo J +7 more
europepmc +3 more sources
Fermentation, 2023 Xaa-Pro dipeptidase (XPD, EC 3.4.13.9; also known as prolidase) catalyzes the hydrolysis of the iminopeptide bond in the trans-Xaa-Pro dipeptides (Xaa represents any amino acid except proline), which makes it find wide applications in food, medical and ...
Zixing Dong +5 more
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