Results 41 to 50 of about 2,180 (185)

Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control

Molecular Ecology, Volume 35, Issue 5, March 2026.
ABSTRACT Malaria, a febrile disease caused by the Plasmodium parasites and transmitted by mosquitoes, is a leading cause of mortality in children under 5 in endemic countries. The widespread deployment of insecticide‐treated bed nets (ITNs) has significantly reduced malaria transmission, but rising levels of insecticide resistance threaten to halt the ...
Harun N. Njoroge, Lilian Namuli, Sanjay C. Nagi, Anastasia Hernandez‐Koutoucheva, Daniel P. McDermott, Erin Knight, Samuel Gonahasa, Amy Lynd, Ambrose Oruni, Catherine Maiteki‐Sebuguzi, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Moses R. Kamya, Grant Dorsey, Janet Hemingway, Sarah G. Staedke, Chris Clarkson, Alistair Miles, Eric R. Lucas, Martin J. Donnelly   +21 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, Volume 600, Issue 3, Page 324-333, February 2026.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Glutathione in Cancer Cell Death [PDF]

, 2011
Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation
Ames, Angel L. Ortega, Arai, Armstrong, Armstrong, Arrick, Arrigo, Azad, Baguley, Baines, Balendiran, Ballatori, Beatrice, Bedikian, Benlloch, Benlloch, Bignold, Biswas, Borst, Boveris, Brdiczka, Brosnan, Bump, Burcham, Calvert, Carrascosa, Carretero, Carretero, Cazanave, Chanas, Chen, Chen, Cheung, Circu, Cole, Conway, Costantini, Costantini, Crook, D'Alessio, Dalton, Dalton, Dang, de Bruin, DeBerardinis, DeGraff, Depeille, Dethmers, Dias, Dickinson, Ekshyyan, Erickson, Estrela, Estrela, Federico, Franco, Franco, Franco, Franco, Friesen, Fulda, Gadsby, Gatti, Gjertsen, Gleave, Gogvadze, Goossens, Gottesman, Guha, Guha, Halestrap, Hall, Hall, Halliwell, Halliwell, Hanigan, Hansen, Hara, Harper, Hayes, Hidalgo, Higuchi, Higuchi, Hochwald, Honda, Ischiropoulos, Janssen-Heininger, Jones, Jose M. Estrela, Kang, Kensler, Keppler, Klaassen, Klasa, Klimberg, Klimberg, Klionsky, Kokoszka, Kowaltowski, Krauskopf, Krebs, Kretz-Remy, Kroemer, Kroemer, Kuhn, Kuo, Kuranaga, Lai, Lee, Leslie, Leslie, Levine, Linsdell, Loe, Loe, Lopes de Menezes, Lorico, Loschen, Lu, Lu, Maher, McDonald, Medina, Meister, Meister, Melis, Mena, Mena, Mieyal, Mistry, Mitchell, Miyake, Morales, Moreira, Morito, Moscow, Nguyen, Obrador, Obrador, Obrador, Ortega, Ortega, Paget, Park, Parmentier, Pastor, Pennington, Petronilli, Priego, Rahman, Rappa, Rebrin, Reisman, Salvador Mena, Savarese, Scherz-Shouval, Schneider, Shacter, Son, Song, Stole, Suthanthiran, Szabo, Terasaki, Terradez, Tormos, Troyano, Um, Usatyuk, Valko, Versantvoort, Wang, Warburg, Wijnholds, Wild, Wise, Wise, Yao, Yuan, Zaman, Zangemeister-Wittke, Zhang, Zhou, Ziegler, Zong   +184 more
core   +2 more sources

Parenteral glutamine in critical illness : just what the gut needs [PDF]

, 2012
The role of glutamine as a metabolic fuel for the starving intestines, its capacity to limit bacterial translocation, lung sepsis and a pro-inflammatory cytokine response are reviewed in the context of uncertainities regarding current recommendations for
Pullicino, Edgar
core  

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarkers of cognitive decline, but their role in early ADAD is unclear.
Lina Pineda‐Lopez, David Aguillon, Juan Villar‐Vesga, Pablo Valderrama‐Carmona, Alejandro Guerrero, Anil Upreti, Said Arevalo‐Alquichire, Laura Correa, Karin Mendez‐Castellanos, Diana Castaño, Gloria P. Cardona‐Gomez, Geysson J. Fernandez, Leo A. Kim, Joseph F. Arboleda‐Velasquez, Rafael Posada‐Duque   +14 more
wiley   +1 more source

Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile. [PDF]

, 2012
International audienceThe catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria.
Antunes, Ana, Barbut, Frédéric, Camiade, Emilie, Courtois, Emmanuelle, Dupuy, Bruno, Martin-Verstraete, Isabelle, Monot, Marc, Rodionov, Dmitry A, Sernova, Natalia V   +8 more
core   +4 more sources

Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug‐Induced Liver Injury

Hepatology Research, Volume 56, Issue 1, Page 111-124, January 2026.
Three metabolites, pyroglutamylglycine (pyroGluGly), phenylalanine (Phe), and phenylalanyltryptophan (PheTrp), were identified as candidate DILI biomarkers. The serum concentrations of pyroGluGly, Phe, and PheTrp demonstrated a high differentiating ability in patients with mixed and cholestatic DILI compared with those in patients who recovered from ...
Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori, Toshio Uraoka, Kazuhide Takata, Koji Ogawa, Kazuhiko Mori, Motonobu Sato, Takayoshi Nishiya, Kazuhiko Takamatsu, Noriaki Arakawa, Takashi Izumi, Ruri Kikura‐Hanajiri, Yasuo Ohno, Yoshiro Saito, Hajime Takikawa   +22 more
wiley   +1 more source

Zinc-selective inhibition of the promiscuous bacterial amide-hydrolase DapE: implications of metal heterogeneity for evolution and antibiotic drug design [PDF]

, 2014
The development of resistance to virtually all current antibiotics makes the discovery of new antimicrobial compounds with novel protein targets an urgent challenge. The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) is an essential
Angelici, Gaetano, Creus, Marc, Nicolet, Stefan, Schmidt, Tobias, Schwede, Torsten, Uda, Narasimha Rao, Upert, Grégory   +6 more
core   +2 more sources

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Early Nutritional Programing: Unlocking the Potential of Fish for Sustainable Aquaculture

Aquaculture Nutrition, Volume 2026, Issue 1, 2026.
Nutritional programing, which explores the link between early nutritional conditions and their long‐term effects on animals, is a developing field within fish biology. Suboptimal nutritional status during early life is strongly associated with a higher risk of metabolic consequences later in life, including permanent growth retardation, impaired neural
Shivendra Kumar, Aditi Banik, Maneesh Kumar Dubey, Prem Prakash Srivastava, Zsuzsanna J. Sandor, Jianguang Qin   +5 more
wiley   +1 more source