Results 271 to 280 of about 22,784 (283)

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors

European Journal of Medicinal Chemistry, 2008
Dipeptidyl peptidase IV (DPP-IV) is a valid drug target for type-2 diabetes and DPP-IV inhibitors have been proven to efficiently improve glucose tolerance. In our study, 3D pharmacophore models were generated using a training set of 22 DPP-IV inhibitors.
I-Lin, Lu, Keng-Chang, Tsai, Yi-Kun, Chiang, Weir-Torn, Jiaang, Ssu-Hui, Wu, Neeraj, Mahindroo, Chia-Hui, Chien, Shiow-Ju, Lee, Xin, Chen, Yu-Sheng, Chao, Su-Ying, Wu   +10 more
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Population Pharmacokinetic/Pharmacodynamic Modelling of Dipeptidyl Peptidase IV Inhibitors

Clinical Pharmacokinetics, 2015
The prevalence of type 2 diabetes has dramatically increased over the past decades, causing high morbidity, mortality and healthcare costs. Dipeptidyl peptidase IV (DPP-4) inhibitors, also called ‘gliptins’, are a relatively new group of antidiabetic agents that target the incretin system.
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Inhibitors of Dipeptidyl Peptidase IV - Recent Advances and Structural Views

Current Topics in Medicinal Chemistry, 2005
Prevalence of type 2 diabetes has increased dramatically in the last decades. Current medicines are not yet capable to efficiently prevent or reverse progression of the disease and its associated comorbidities. As a consequence, there is a great need for novel antidiabetic drugs.
Daniel, Hunziker, Michael, Hennig, Jens-Uwe, Peters   +2 more
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Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors

Bioorganic & Medicinal Chemistry Letters, 2012
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
Betty, Lam, Zhiyuan, Zhang, Jeffery A, Stafford, Robert J, Skene, Lihong, Shi, Stephen L, Gwaltney   +5 more
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New Fluorinated Pyrrolidine and Azetidine Amides as Dipeptidyl Peptidase IV Inhibitors.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Bernard, Hulin, Shawn, Cabral, Michael G, Lopaze, Maria A, Van Volkenburg, Kim M, Andrews, Janice C, Parker   +5 more
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Novel compounds as dipeptidyl peptidase IV (dpp iv) inhibitors

2009
The present invention is related to novel compounds of the general formula (A), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods of making of the above compounds, and their use as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors, which are useful in the treatment or ...
Arora, Sudershan, Sinha, Neelima, Nair, Prathap, Chakka, Sai Kumar, Hajare, Anil, Reddy, Azmi, Patil, Pravin, Sayyed, Majid, Kamboj, Rajender Kumar, Swamy, K.H. Sreedhara, Goel, Rajan   +10 more
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Dipeptidyl peptidase IV inhibitors

2016
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Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes

Journal of Medicinal Chemistry, 2004
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Novel dipeptidyl peptidase IV inhibitors with antiarthritic effects

Drugs of the Future, 1999
null Ohnuki, T., null Yamada, M., null Sugita, T.   +2 more
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Boronic acid inhibitors of dipeptidyl peptidase IV

1995
Roger J. Snow, William W. Bachovchin
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