Results 31 to 40 of about 5,638 (129)

Immunoproteomics of peptidases from Lactobacillus helveticus [PDF]

, 2009
Milk proteins beyond their high nutritional quality are a source of peptides with biological activity. These bioactive peptides would exert different activities in vivo, affecting the cardiovascular, endocrine, immune, digestive or nervous systems.
Mollé, Daniel, Arnould, Céline, Dupont, Didier, Rolet-Répécaud, Odile, Piot, Michel, Buchin, S, Jardin, Julien, Gagnaire Soumet, Valérie   +7 more
core   +8 more sources

LOCALIZATION OF PEPTIDASES IN LACTOCOCCI [PDF]

, 1992
The localization of two aminopeptidases, an X-prolyl-dipeptidyl aminopeptidase, an endopeptidase, and a tripeptidase in Lactococcus lactis was studied. Polyclonal antibodies raised against each purified peptidase are specific and do not cross-react with ...
TAN, PST, BOQUIEN, CY, CHAPOTCHARTIER, MP, KONINGS, WN, ROUSSEAU, M, POS, KM, GRIPON, JC   +6 more
core   +2 more sources

An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei [PDF]

, 2015
The serine peptidases of Trypanosoma brucei have been viewed as potential drug targets. In particular, the S9 prolyl oligopeptidase subfamily is thought to be a good avenue for drug discovery.
Brown, Elaine, Catherine X Moss, Van der Veken, Pieter, Jeremy C. Mottram (112563), Alana Hamilton, Catherine X. Moss (713740), Mottram, Jeremy C., Hamilton, Alana, Elaine Brown (225503), Pieter Van der Veken, Jeremy C Mottram, Moss, Catherine X., Pieter Van der Veken (713741), Mottram, Jeremy, Koen Augustyns (713742), Elaine Brown, Koen Augustyns, Augustyns, Koen, Alana Hamilton (425314)   +18 more
core   +1 more source

In silico prediction and structural characterization of multifunctional bioactive peptides released from olive proteins

Journal of the Science of Food and Agriculture, Volume 106, Issue 9, Page 5463-5482, July 2026.
Abstract BACKGROUND Olive (Olea europaea L.) byproducts, such as seeds and leaves, are abundant agro‐industrial residues and represent underexplored protein sources with potential health relevance. However, the repertoire of bioactive peptides that may be released from olive proteins during gastrointestinal digestion remains poorly characterized.
Teresa Gonzalez‐de la Rosa, Luna Barrera‐Chamorro, Africa Fernandez‐Prior, Elvira Marquez‐Paradas, Maria Torrecillas‐Lopez, Fernando Rivero‐Pino, Sergio Montserrat‐de la Paz   +6 more
wiley   +1 more source

Kinoplastid papain-like cystein peptidases [PDF]

, 2009
Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L.
Dietmar Steverding, Caffrey, Conor R., Steverding, Dietmar, Conor R. Caffrey   +3 more
core   +1 more source

Exploring Nirmatrelvir Derivatives Through P2 Substituent Modifications and Warhead Innovations Targeting the Main Protease of SARS‐CoV‐2

Archiv der Pharmazie, Volume 358, Issue 11, November 2025.
This study explores structural tuning of SARS‐CoV‐2 Mpro inhibitors through P2 position substitutions and novel warheads. Combining computational modeling and biochemical assays, we found that hydrophobic π‐rich groups and uncommon warheads like fluoro‐vinylsulfone or nitrile enhance potency.
Felipe Cardoso Prado Martins, Johannes Lang, Fernanda dos Reis Rocho, Xianxian Wang, Vinícius Bonatto, Jerônimo Lameira, Christian Klein, Carlos Alberto Montanari   +7 more
wiley   +1 more source

The cerebellum in epilepsy

Epilepsia, Volume 66, Issue 6, Page 1773-1792, June 2025.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source

The study of a new and specific proline cleaving peptidase from bovine serum [PDF]

, 2003
Prolyl oligopeptidase is a serine peptidase characterised by oligoendopeptidase activity. Definitive evidence for the discrete biological role of prolyl oligopeptidase remains unknown, though its role in the maturation and degradation of peptide hormones
Collins, Patrick
core  

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern, Exequiel O. J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul W. Denny, Patrick G. Steel   +7 more
wiley   +1 more source

Gut Microbial Dipeptidyl Peptidase-4 and Associated Prolyl Tripeptidyl Peptidases: A Novel Classification and Response to Inhibitors

Abstract In recent decades, microbiome research has progressed profoundly from exploring microbial diversity to uncovering host-microbial-isozymes (HMI). The understanding of the implications for human health of one such HMI, microbially derived dipeptidyl peptidases, remains limited, despite their structural and functional similarities
Mashael Aljumaah, Israa Isawi, Jeff Roach, Yunan Hu, Suzanne Dagher, Jose Bruno-Barcena, Rufaida Al-Zoubi, M. Andrea Azcarate-Peril   +7 more
openaire   +1 more source