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Effect of dipeptidyl peptidase‐4 inhibitors on complement activation
Diabetes/Metabolism Research and Reviews, 2020AbstractBackgroundAdverse activation of the complement cascade in the innate immune system appears to be involved in development of vascular complications in diabetes. Dipeptidyl peptidase‐4 (DPP‐4) is a cell surface serine protease expressed in a variety of tissues.
Ingeborg T. Hoffmann‐Petersen +7 more
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Renal outcomes with dipeptidyl peptidase-4 inhibitors
Diabetes & Metabolism, 2018Dipeptidyl peptidase-4 inhibitors (DPP-4is) are increasingly being used in the management of type 2 diabetes (T2D). The present review summarizes the current knowledge of the effects of DPP-4is on renal outcomes by analyzing the experimental preclinical data, the effects of DPP-4is on urinary albumin-creatinine ratios (UACRs) and estimated glomerular ...
Scheen, André, DELANAYE, Pierre
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Dipeptidyl peptidase-4 inhibition and renoprotection
Current Opinion in Nephrology and Hypertension, 2017This article analyzes the potential beneficial effects of dipeptidyl peptidase (DPP)-4 inhibitors on renal diseases.The pathological significance of DPP-4, either dependent or independent on catalytic activities, on renal diseases has been reported in preclinical studies.
Yuta, Takagaki +2 more
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Dipeptidyl peptidase-4 inhibitors
2016Dipeptidyl peptidase (DPP)-4 inhibitors inhibit the activity of the enzyme responsible for the initial rapid degradation of the incretin hormones, thereby enhancing their antihyperglycemic effects.
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Periostin and Dipeptidyl Peptidase-4
Immunology and Allergy Clinics of North America, 2018Claire Emson +3 more
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Dipeptidyl Peptidase-4 – A Comprehensive Review
Current Enzyme InhibitionType 2 diabetes mellitus is a growing global public health issue, with its prevalence projected to increase in the coming decades. It is one of the most prevalent and growing global health concerns, affecting millions of individuals worldwide. The condition is classified into two primary types: Type 1 diabetes,
Venkatesan Parthasarathi +1 more
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Discovery of Food-Derived Dipeptidyl Peptidase IV Inhibitory Peptides: A Review
International Journal of Molecular Sciences, 2019Rui Liu, Hao Wu, Rui Liu
exaly