Genetic Study on the Effect of the Antidiabetic Drug (Sitagliptin) on DNA and Chromosomes of Human Lymphocyte Culture [PDF]
The Egyptian Journal of Histology, 2021 Background: Diabetes mellitus is a worsening worldwide health problem. It constitutes a major global health concern. Sitagliptin selectively inhibits dipeptidyl peptidase-4 (DPP-4) to manage type 2 diabetes mellitus (T2DM). It regulates the blood glucose
Rania Yassien +4 more
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Pakistan Journal of Pharmaceutical Sciences, 2023 Pharmaceutical substance sitagliptin has long been used to treat diabetes. However, subsequent researches have shown that sitagliptin has additional therapeutic effects. Anti-inflammatory effects are observed.
Muhammad Abdullah +6 more
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Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats [PDF]
PeerJ, 2020 Increasing evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. We hypothesized that maternal sitagliptin intervention may improve glucose intolerance through gut targeting. Female Sprague-Dawley (SD) rats were fed a
Qian Zhang +7 more
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The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Fatty liver disease (FLD) is a disorder related to accumulation of excess fat within the hepatocytes. In this study, the effects of Berberine, a natural compound, and Sitagliptin as a DPP-4 inhibitor, were observed in a rat model of FLD ...
Soraya Mehrdoost +3 more
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Identification of sitagliptin binding proteins by affinity purification mass spectrometry
Acta Biochimica et Biophysica Sinica, 2022 Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with increasing incidence. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin has been used for the treatment of T2DM worldwide.
Wang Xue-Ning +12 more
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Combined effects of synbiotic and sitagliptin versus sitagliptin alone in patients with nonalcoholic fatty liver disease [PDF]
Clinical and Molecular Hepatology, 2018 Background/Aims Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases in recent years. The aim of this study was to evaluate the effects of sitagliptin with and without a synbiotic supplement in the treatment of ...
Saba Sayari +2 more
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Induction of Energy Expenditure by Sitagliptin Is Dependent on GLP-1 Receptor. [PDF]
PLoS ONE, 2015 Sitagliptin (SG) increases serum GLP-1 (Glucagon-like peptide-1) through inhibition of the hormone degradation. Resistant starch (RS) induces GLP-1 expression by stimulating L-cells in the intestine.
Felicia Goldsmith +9 more
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Frontiers in Endocrinology, 2022 PurposeDipeptidyl peptidase-4 inhibitors (DPP-4I), key regulators of the actions of incretin hormones, exert anti-hyperglycemic effects in type 2 diabetes mellitus (T2DM) patients.
Xingchun Wang +6 more
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Frontiers in Endocrinology, 2023 BackgroundDiabetes has become a serious global public health problem. With the increasing prevalence of type 2 diabetes mellitus (T2DM), the incidence of complications of T2DM is also on the rise.
Jian-hong Qi +6 more
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Attenuation of acrylamide-induced neurotoxicity by supplementation of sitagliptin in Wistar rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Acrylamide (ACR) induces neurotoxicity in humans and animals through different mechanisms. Sitagliptin is a type-2 diabetes medication with neuroprotective properties.
Mahboobeh Navabi +3 more
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