Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate [PDF]
Molecules, 2018 Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine ...
Jiangang Yu
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Stability of extemporaneously prepared sitagliptin phosphate solution. [PDF]
PLoS ONE, 2022 Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used orally in conjunction with diet and exercise to control sugar levels in type 2 Diabetes Mellitus patients.
Abdel Naser Zaid +7 more
doaj +5 more sources
Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Phosphate Accelerates Cellular Cholesterol Efflux in THP-1 Cells [PDF]
Biomolecules, 2023 Cholesterol efflux is a major atheroprotective function of high-density lipoproteins (HDLs) which removes cholesterol from the foam cells of lipid-rich plaques in Type 2 diabetes.
Tomohiro Komatsu +7 more
doaj +4 more sources
Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model [PDF]
Scientific Reports, 2023 The solubility of an anti-hyperglycemic agent drug, (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4] triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine (also known as Sitagliptin phosphate) in supercritical carbon dioxide ...
Nedasadat Saadati Ardestani +4 more
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Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization [PDF]
Frontiers in EndocrinologyAimTo investigate the effect and mechanism of Sitagliptin phosphate on inflammation and macrophage polarization in a mouse model of type 2 diabetes.MethodsIn vitro, Raw264.7 cells were cultured with a high concentration of glucose (HG) and sitagliptin ...
Xiaoxia Hu, Yalong Li, Xinyue Liu
doaj +4 more sources
Two methods for the preparation of sitagliptin phosphate via chemical resolution and asymmetric hydrogenation. [PDF]
RSC Adv, 2021 Two effective processes have been developed for the preparation of sitagliptin phosphate.
Ye F +5 more
europepmc +4 more sources
Improved Chromatographic Separation of Sitagliptin Phosphate and Metformin Hydrochloride. [PDF]
Int J Biomed Sci, 2015 New UPLC method was developed for determination of sitagliptin and metformin using Symmetry C18 column (100 mm × 2.1 mm, 2.2 μm) and isocratic elution (methanol 20%), pH (3.5) as a mobile phase. The ultraviolet detector was operated at 220 nm and the column temperature was 50°C. Linearity parameters were acceptable over the concentration ranges of 2-12
Hendy MS.
europepmc +3 more sources
Pharmaceutical Development and Technology, 2022 Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets.
Daniel Zakowiecki, Tobias Hes
exaly +3 more sources
Review of sitagliptin phosphate: a novel treatment for type 2 diabetes [PDF]
Vascular Health and Risk Management, 2007 Baptist GallwitzDept. Medicine IV, Eberhard Karls University, Tuebingen, GermanyAbstract: Sitagliptin (Januvia®, Merck Pharmaceuticals) is a dipeptidyl-peptidase inhibitor (DPP-4 inhibitor) that has recently been approved for the therapy of type 2 ...
Baptist Gallwitz
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Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate [PDF]
Journal of Pharmaceutical Sciences, 2022 Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing ...
Naseem A Charoo +2 more
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