Pharmaceutical Development and Technology, 2022 Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets.
Daniel Zakowiecki, Tobias Hess
exaly +3 more sources
Formulation, Development and Characterization of Transdermal Patches of Sitagliptin Phosphate [PDF]
Journal of Drug Delivery and Therapeutics, 2019 Sitagliptin is a dipeptidyl peptidase 4-(DPP-4) inhibitor with glucose controlling capabilities that was effectively used for treating diabetes in the past. However, the oral administration of this drug caused such severe side effects that it was removed from the market.
Rekha Pathak +2 more
openaire +3 more sources
Improved Chromatographic Separation of Sitagliptin Phosphate and Metformin Hydrochloride [PDF]
International Journal of Biomedical Science, 2015 New UPLC method was developed for determination of sitagliptin and metformin using Symmetry C18 column (100 mm × 2.1 mm, 2.2 μm) and isocratic elution (methanol 20%), pH (3.5) as a mobile phase. The ultraviolet detector was operated at 220 nm and the column temperature was 50°C. Linearity parameters were acceptable over the concentration ranges of 2-12
Hendy MS.
openaire +3 more sources
Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study [PDF]
Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay +22 more
wiley +2 more sources
The SGLT2i “canagliflozin” and the DPP-4i “sitagliptin” mitigate hypertensive nephropathy in adult male rats by modulating the Ang II/RAGE/Nox4/NLRP3 cascade [PDF]
Frontiers in PhysiologyBackgroundHypertensive nephropathy (HN) with progressive renal damage is a common consequence of arterial hypertension (HTN). This study addresses the renoprotective attributes of the sodium-glucose cotransporter-2 inhibitor canagliflozin (Cana) and the ...
Fatma E. Hassan +5 more
doaj +2 more sources
INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH, 2017 A new simple, rapid, specific, accurate, precise and novel Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the estimation of Sitagliptin Phosphate in the pharmaceutical dosage form. The chromatographic separation for Sitagliptin was achieved with mobile phase containing methanol, Thermoscientific C18 column,
D, Sireesha +3 more
openaire +5 more sources
A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones [PDF]
Advanced Science, Volume 13, Issue 46, 17 August 2026.Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim +5 more
wiley +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition [PDF]
Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +2 more sources
NiO/CuO@Graphene oxide-modified electrode for sensitive detection of an antidiabetic drug [PDF]
Scientific ReportsA new, simple, and cost-effective electrochemical sensor was developed for the determination of Sitagliptin phosphate monohydrate (SP) in powder, pharmaceutical tablet form and biological fluids as spiked plasma.
Essam N. Labeeb +3 more
doaj +2 more sources
Beyond glycemic control: differential effects of empagliflozin and sitagliptin on insulin sensitivity and a shared increase in adropin in type 2 diabetes [PDF]
BMC Endocrine DisordersBackground Type 2 diabetes mellitus (T2DM) is characterized by metabolic and inflammatory disturbances beyond hyperglycemia. Hepatokines such as adropin have emerged as regulators of insulin resistance and vascular function, yet the comparative metabolic
Otbah Salim Taha +4 more
doaj +2 more sources