Results 1 to 10 of about 208 (89)

Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate [PDF]

Molecules, 2018
Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine ...
Haoling Gao, Jiangang Yu, Chengsheng Ge, Qun Jiang   +3 more
doaj   +7 more sources

Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioequivalence Studies [PDF]

Pharmaceutics, 2023
The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a treatment for type ...
So-Jin Kang, Joo-Eun Kim
doaj   +4 more sources

Simultaneous Determination of Sitagliptin Phosphate Monohydrate and Metformin Hydrochloride in Tablets by a Validated UPLC Method [PDF]

Scientia Pharmaceutica, 2012
A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase ultra performance liquid chromatographic (UPLC) method for the simultaneous determination of Sitagliptin phosphate monohydrate and Metformin hydrochloride in pharmaceutical dosage forms.
Malleswararao CS, Suryanarayana MV, Mukkanti K.   +2 more
exaly   +5 more sources

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate [PDF]

Journal of Pharmaceutical Sciences, 2022
Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing ...
Tomokazu Tajiri, Naseem Charoo, James Polli   +2 more
exaly   +3 more sources

NiO/CuO@Graphene oxide-modified electrode for sensitive detection of an antidiabetic drug [PDF]

Scientific Reports
A new, simple, and cost-effective electrochemical sensor was developed for the determination of Sitagliptin phosphate monohydrate (SP) in powder, pharmaceutical tablet form and biological fluids as spiked plasma.
Essam N. Labeeb, Mahmoud A. Hefnawy, Shymaa S. Medany, Eman Yossri Frag   +3 more
doaj   +2 more sources

Green and sustainable LC-APCI-MS/MS method for simultaneous quantification of genotoxic nitrosamines in antidiabetic medication: sitagliptin [PDF]

BMC Chemistry
The International Agency for Research on Cancer categorized nitrosamines as potential or probable human carcinogens. Hence, nitrosamine impurities should be controlled to minimize the cancer risk.
Sriram Pepakayala, Venkata Nadh Ratnakaram, Yuvaraj Zunjarrao, Yogesh Kumar Lohia   +3 more
doaj   +2 more sources

Validation of a rapid and economical RP-HPLC method for simultaneous determination of metformin hydrochloride and sitagliptin phosphate monohydrate: Greenness evaluation using AGREE score

Pakistan Journal of Pharmaceutical Sciences, 2022
Reported high performance liquid chromatographic (HPLC) methods for estimating metformin hydrochloride (MET) and sitagliptin phosphate monohydrate (SIT) are either laborious or contain higher proportions of organic solvents in mobile phase, thus ...
Aqeela Raza, Syed Hassan Murtaza, Sana Hanif, Javed Iqbal, Ijaz Ali, Tayyaba Aftab, Rouheena Shakir, Rushda Bedar, Muhammad Ali Syed   +8 more
doaj   +3 more sources

Phytochemical Screening and Antidiabetic Potential of <i>Paeonia emodi</i> in Alloxan-Induced Diabetic Rats: Investigative Study Toward Possible Mechanism. [PDF]

Food Sci Nutr
The findings of the current investigations indicated that the Butanol fraction obtained from Paeonia emodi possesses strong anti‐diabetic, pancreatic protective, hepatoprotective, anti‐oxidant properties and alleviates Alloxan‐induced liver and pancreatic damage in diabetic rats.
Fan J, Ibrar M, Khan MA, Abdullah, Saeed Jan M, Shabnam M, Rehman MU.   +6 more
europepmc   +2 more sources

Stability indicating HPTLC method for simultaneous analysis of sitagliptin phosphate monohydrate and pioglitazone hydrochloride with greenness assessment using AGREE, ESA, BAGI and CACI

Discover Chemistry
A stability-indicating high-performance thin-layer chromatographic (HPTLC) method was developed for the simultaneous determination of sitagliptin phosphate monohydrate and pioglitazone hydrochloride in a combined antidiabetic mixture.
Riddhi B. Nagar, Rashmi Korat, Zarna Dedania, Vineet C. Jain, Ashok H. Akabari   +4 more
doaj   +2 more sources

Development and validation of stability-indicating high-performance thin-layer chromatography method for estimation of sitagliptin phosphate monohydrate in bulk and in pharmaceutical formulation

Acta Chromatographica, 2014
Summary A simple, selective, precise, and stability-indicating high-performance thinlayer chromatographic method for analysis of sitagliptin phosphate both in a bulk and in pharmaceutical formulation has been developed and validated. The method employed high-performance thin-layer chromatography (HPTLC) aluminium plates precoated with silica gel 60 RP ...
P. S. Jain, A. J. Chaudhari, S. J. Surana   +2 more
exaly   +2 more sources