Results 1 to 10 of about 216 (92)
Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate [PDF]
Molecules, 2018 Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine ...
Haoling Gao +3 more
doaj +8 more sources
Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioequivalence Studies [PDF]
Pharmaceutics, 2023 The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a treatment for type ...
So-Jin Kang, Joo-Eun Kim
doaj +5 more sources
Simultaneous Determination of Sitagliptin Phosphate Monohydrate and Metformin Hydrochloride in Tablets by a Validated UPLC Method [PDF]
Scientia Pharmaceutica, 2012 A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase ultra performance liquid chromatographic (UPLC) method for the simultaneous determination of Sitagliptin phosphate monohydrate and Metformin hydrochloride in pharmaceutical dosage forms.
Khagga Mukkanti
exaly +6 more sources
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate [PDF]
Journal of Pharmaceutical Sciences, 2022 Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing ...
Naseem A Charoo +2 more
exaly +4 more sources
Acta Chromatographica, 2014 Summary A simple, selective, precise, and stability-indicating high-performance thinlayer chromatographic method for analysis of sitagliptin phosphate both in a bulk and in pharmaceutical formulation has been developed and validated. The method employed high-performance thin-layer chromatography (HPTLC) aluminium plates precoated with silica gel 60 RP ...
P. S. Jain +2 more
exaly +3 more sources
Sitagliptin Phosphate Monohydrate
, 2011 Biological target: Sitagliptin is a β-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DPP4), a serine protease with membrane cell-signalling and soluble N-terminal proline peptidase activity. As a result, sitagliptin inhibits the in vivo degradation of the incretins, such as glucagon-like peptide-1 (GLP-1), which are endogenous glucoregulatory ...
Vitomir Sunjic +2 more
exaly +3 more sources
NiO/CuO@Graphene oxide-modified electrode for sensitive detection of an antidiabetic drug [PDF]
Scientific ReportsA new, simple, and cost-effective electrochemical sensor was developed for the determination of Sitagliptin phosphate monohydrate (SP) in powder, pharmaceutical tablet form and biological fluids as spiked plasma.
Essam N. Labeeb +3 more
doaj +2 more sources
Langmuir, 2022 Cross-contamination during pharmaceutical drug manufacturing can result in expensive recalls. To counter that, companies spend significant time and resources to ensure equipment cleanliness, often relying on the compound solubility data in various solvents as the main indicator of cleaning success.
Hui Ling Chan +5 more
openaire +3 more sources
Green and sustainable LC-APCI-MS/MS method for simultaneous quantification of genotoxic nitrosamines in antidiabetic medication: sitagliptin [PDF]
BMC ChemistryThe International Agency for Research on Cancer categorized nitrosamines as potential or probable human carcinogens. Hence, nitrosamine impurities should be controlled to minimize the cancer risk.
Sriram Pepakayala +3 more
doaj +2 more sources
Solid-State Characterization of Different Crystalline Forms of Sitagliptin. [PDF]
Materials (Basel), 2019 Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-4, used for the treatment of type 2 diabetes mellitus. The crystal structure of active pharmaceutical solids determines their physical and chemical properties.
Stofella NCF +8 more
europepmc +2 more sources