Results 11 to 20 of about 383,013 (128)

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE, SITAGLIPTIN PHOSPHATE MONOHYDRATE AND METFORMIN HYDROCHLORIDE USING DOE APPROACH

Rasayan Journal of Chemistry
For simultaneous estimation of DAPA, SITA, and MET in combination, using experiment design, the HPTLC technique was created and validated. The optimized HPTLC technique utilized a mobile phase comprising EA: Methanol: ammonia: GAA in then the ratio of 6.8:2.7:0.4:0.1, V/V/V/V).
null A. B. Patel, null P. H. Patel
exaly   +2 more sources

Solid-State Characterization of Different Crystalline Forms of Sitagliptin. [PDF]

Materials (Basel), 2019
Sitagliptin is an inhibitor of the enzyme dipeptidyl peptidase-4, used for the treatment of type 2 diabetes mellitus. The crystal structure of active pharmaceutical solids determines their physical and chemical properties.
Stofella NCF, Veiga A, Oliveira LJ, Montin EF, Andreazza IF, Carvalho Filho MAS, Bernardi LS, Oliveira PR, Murakami FS.   +8 more
europepmc   +2 more sources

Comparison of mobility shift affinity capillary electrophoresis and capillary electrophoresis frontal analysis for binding constant determination between human serum albumin and small drugs

ELECTROPHORESIS, Volume 43, Issue 16-17, Page 1724-1734, September 2022., 2022
Abstract In this study, two capillary electrophoresis–based ligand binding assays, namely, mobility shift affinity capillary electrophoresis (ms‐ACE) and capillary electrophoresis‐frontal analysis (CE‐FA), were applied to determine binding parameters of human serum albumin toward small drugs under similar experimental conditions.
Hana Mlčochová, Ratih Ratih, Lenka Michalcová, Hermann Wätzig, Zdeněk Glatz, Matthias Stein   +5 more
wiley   +1 more source

Colonic Delivery of α‐Linolenic Acid by an Advanced Nutrient Delivery System Prolongs Glucagon‐Like Peptide‐1 Secretion and Inhibits Food Intake in Mice

Molecular Nutrition &Food Research, Volume 66, Issue 4, February 2022., 2022
Sustained delivery of nutritional compounds like α‐linolenic acid by porous silicon particles to the distal gastrointestinal tract stimulates glucagon‐like peptide‐1 secretion which inhibits food intake. Our findings may open a novel field of research on appetite management by applying nutrients without significant caloric load to endogenously release ...
Remi Kamakura, Ghulam Shere Raza, Ermei Mäkilä, Joakim Riikonen, Miia Kovalainen, Yoichi Ueta, Vesa‐Pekka Lehto, Jarno Salonen, Karl‐Heinz Herzig   +8 more
wiley   +1 more source

Abrus precatorius Leaf Extract Reverses Alloxan/Nicotinamide‐Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP‐1, and Glucagon) and Enzymatic (α‐Amylase/α‐Glucosidase) Modulation

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Background. Abrus precatorius is used in folk medicine across Afro‐Asian regions of the world. Earlier, glucose lowering and pancreato‐protective effects of Abrus precatorius leaf extract (APLE) was confirmed experimentally in STZ/nicotinamide‐induced diabetic rats; however, the underlying mechanism of antidiabetic effect and pancreato‐protection ...
Alex Boye, Victor Yao Atsu Barku, Desmond Omane Acheampong, Eric Gyamerah Ofori, Rui Liu   +4 more
wiley   +1 more source

Development and Validation of Analytical Method for Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Sitagliptin Phosphate Monohydrate in Tablet Dosage Form

International Journal of Science and Research (Raipur, India)
Priyanka Patil, Chainesh Shāh, Umesh Upadhyay   +2 more
exaly   +2 more sources

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF GLICLAZIDE AND SITAGLIPTIN PHOSPHATE MONOHYDRATE IN BULK AND PHARMACEUTICAL DOSAGE FORM [PDF]

, 2015
Objective: The present study describes a simple, accurate, precise, specific and economical UV spectrophotometric method for simultaneous estimation of Gliclazide (GLZ) and Sitagliptin phosphate monohydrate (SPM) in bulk and pharmaceutical dosage form ...
Reichal, C. Rubina, Rao, M. Gopal
core   +1 more source

A Simple and Sensitive HPTLC Method for Simultaneous Determination of Metformin Hydrochloride and Sitagliptin Phosphate in Tablet Dosage Form [PDF]

, 2013
A simple, rapid, and precise high-performance thin-layer chromatographic (HPTLC) method for simultaneous estimation of two antidiabetic drugs, metformin hydrochloride and sitagliptin phosphate, in tablet dosage form has been developed and validated ...
Bhavesh H. Patel, Darshana K. Modi, Punit B. Parejiya   +2 more
core   +1 more source

AI-guided optimization and eco-friendly assessment of in lab stability-indicating HPLC method for empagliflozin and sitagliptin in combined pharmaceutical dosage form

Results in Chemistry
An accurate analytical method is necessary for accurate quantification and stability assessment of novel antidiabetic fixed dose combination of empagliflozin and sitagliptin phosphate monohydrate.
Ashok H. Akabari, Ashim Kumar Sen, Yadav Ragini, Ketan V. Shah, Mohammad Khishe, Ghanshyam G. Tejani   +5 more
doaj   +1 more source

Simultaneous determination of sitagliptin and metformin in ternary mixture with sitagliptin acid degradation product [PDF]

, 2013
In this work, the acidic degradation product of sitagliptin phosphate monohydrate (STG) was synthesized, separated and its structure was elucidated.
El-Bagary, Ramzia Ismail, Ayoub, Bassam Mahfouz, Elkady, Ehab Farouk   +2 more
core   +1 more source