Results 11 to 20 of about 208 (89)

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE, SITAGLIPTIN PHOSPHATE MONOHYDRATE AND METFORMIN HYDROCHLORIDE USING DOE APPROACH

Rasayan Journal of Chemistry
For simultaneous estimation of DAPA, SITA, and MET in combination, using experiment design, the HPTLC technique was created and validated. The optimized HPTLC technique utilized a mobile phase comprising EA: Methanol: ammonia: GAA in then the ratio of 6.8:2.7:0.4:0.1, V/V/V/V).
null A. B. Patel, null P. H. Patel
exaly   +2 more sources

Comparison of mobility shift affinity capillary electrophoresis and capillary electrophoresis frontal analysis for binding constant determination between human serum albumin and small drugs

ELECTROPHORESIS, Volume 43, Issue 16-17, Page 1724-1734, September 2022., 2022
Abstract In this study, two capillary electrophoresis–based ligand binding assays, namely, mobility shift affinity capillary electrophoresis (ms‐ACE) and capillary electrophoresis‐frontal analysis (CE‐FA), were applied to determine binding parameters of human serum albumin toward small drugs under similar experimental conditions.
Hana Mlčochová, Ratih Ratih, Lenka Michalcová, Hermann Wätzig, Zdeněk Glatz, Matthias Stein   +5 more
wiley   +1 more source

Colonic Delivery of α‐Linolenic Acid by an Advanced Nutrient Delivery System Prolongs Glucagon‐Like Peptide‐1 Secretion and Inhibits Food Intake in Mice

Molecular Nutrition &Food Research, Volume 66, Issue 4, February 2022., 2022
Sustained delivery of nutritional compounds like α‐linolenic acid by porous silicon particles to the distal gastrointestinal tract stimulates glucagon‐like peptide‐1 secretion which inhibits food intake. Our findings may open a novel field of research on appetite management by applying nutrients without significant caloric load to endogenously release ...
Remi Kamakura, Ghulam Shere Raza, Ermei Mäkilä, Joakim Riikonen, Miia Kovalainen, Yoichi Ueta, Vesa‐Pekka Lehto, Jarno Salonen, Karl‐Heinz Herzig   +8 more
wiley   +1 more source

Development and Validation of Analytical Method for Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Sitagliptin Phosphate Monohydrate in Tablet Dosage Form

International Journal of Science and Research (Raipur, India)
Axita Parmar, Priyanka Patil, Krishna Soni, Chainesh Shah, Umesh Upadhyay   +4 more
exaly   +2 more sources

Abrus precatorius Leaf Extract Reverses Alloxan/Nicotinamide‐Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP‐1, and Glucagon) and Enzymatic (α‐Amylase/α‐Glucosidase) Modulation

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Background. Abrus precatorius is used in folk medicine across Afro‐Asian regions of the world. Earlier, glucose lowering and pancreato‐protective effects of Abrus precatorius leaf extract (APLE) was confirmed experimentally in STZ/nicotinamide‐induced diabetic rats; however, the underlying mechanism of antidiabetic effect and pancreato‐protection ...
Alex Boye, Victor Yao Atsu Barku, Desmond Omane Acheampong, Eric Gyamerah Ofori, Rui Liu   +4 more
wiley   +1 more source

AI-guided optimization and eco-friendly assessment of in lab stability-indicating HPLC method for empagliflozin and sitagliptin in combined pharmaceutical dosage form

Results in Chemistry
An accurate analytical method is necessary for accurate quantification and stability assessment of novel antidiabetic fixed dose combination of empagliflozin and sitagliptin phosphate monohydrate.
Ashok H. Akabari, Ashim Kumar Sen, Yadav Ragini, Ketan V. Shah, Mohammad Khishe, Ghanshyam G. Tejani   +5 more
doaj   +1 more source

High Cell Density Cultivation Combined with high Specific Enzyme Activity: Cultivation Protocol for the Production of an Amine Transaminase from Bacillus megaterium in E. coli

ChemBioChem, Volume 25, Issue 9, May 2, 2024.
A fed‐batch protocol is established for the production of an amine transaminase of Bacillus megaterium. Hereby, the main goal is to reach high cell densities accompanied by high titers of active enzyme. Feed rate, inducer concentration, and post‐induction temperature were key parameters of the investigation. Abstract High cell density cultivation is an
Berit Rothkranz, Matthias Rieb, Evelin Lisa Unrau, Ilona Frindi‐Wosch, Johannes Hemmerich, Torsten Sehl, Dörte Rother   +6 more
wiley   +1 more source

Review Of the Combination Dosage Form of Sitagliptin Phosphate Monohydrate and Dapagliflozin Propanediol Monohydrate as an Anti-Diabetic Agent

Sitagliptin acting as Anti-Diabetic agent (Dipeptidyl peptidase-4 inhibitor) which boosts post prandial insulin release decreases Glucagon secretion and lower mean time as well as fasting blood glucose in type 2 diabetes mellitus. There is a strong rationale for combining a DPP-4i and a SGLT2i in patients with T2D because the two drugs exert different ...
openaire   +1 more source

UEG Week 2024 Moderated Posters

United European Gastroenterology Journal, Volume 12, Issue S8, Page 201-664, October 2024.
wiley   +1 more source

Formulation development and evaluation of Sitagliptin Phosphate Monohydrate sustained release tablet by using natural polymers

In 2007, sitagliptin, the first drug in a new family of oral glucose-lowering drugs, was introduced to the UK market. When hyperglycemia is present, it suppresses the secretion of glucagon and increases the secretion of insulin. The goal of the current study is to use lactose as a diluent in a direct compression approach to create a novel drug delivery
openaire   +1 more source