Sitagliptin acting as Anti-Diabetic agent (Dipeptidyl peptidase-4 inhibitor) which boosts post prandial insulin release decreases Glucagon secretion and lower mean time as well as fasting blood glucose in type 2 diabetes mellitus. There is a strong rationale for combining a DPP-4i and a SGLT2i in patients with T2D because the two drugs exert different ...
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In 2007, sitagliptin, the first drug in a new family of oral glucose-lowering drugs, was introduced to the UK market. When hyperglycemia is present, it suppresses the secretion of glucagon and increases the secretion of insulin. The goal of the current study is to use lactose as a diluent in a direct compression approach to create a novel drug delivery
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ABSTRACT:For measuring EMPA and SPM in bulk and pharmaceutical forms to created a accurate and affordable UVspectrophotometric method. Both tested medications in a water and methanol mix (70:30). EMPA absorbs light at 224nm and SPM at 267 nm, which we found by scanning light wavelengths from 200 to 400nm.
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Diabetes affected 10.5% of adults worldwide and was responsible for the equivalent of 1 death every 5 seconds in 2021 according to the International Diabetes Federation. This number is expected to increase in the next years, so there is an urgent need to
Vicente, Ana Catarina Lourenço
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Development and Validation for Quantification of 7-Nitroso Impurity in Sitagliptin by Ultraperformance Liquid Chromatography with Triple Quadrupole Mass Spectrometry. [PDF]
Molecules, 2022 Chittireddy HNPR +7 more
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Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin-Metformin Fixed-Dose Combination Compared with the Originator Products. [PDF]
Diabetes Ther, 2023 Schnaars Y +8 more
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Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents. [PDF]
Molecules, 2023 Mathur V +9 more
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Development of an In Vitro-In Vivo Correlation for Sitagliptin and Metformin Prolonged-release Tablet Formulations [PDF]
Turk J Pharm Sci, 2021 Boddu R +5 more
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Transcriptomic Analysis Reveals That Retinal Neuromodulation Is a Relevant Mechanism in the Neuroprotective Effect of Sitagliptin in an Experimental Model of Diabetic Retinopathy. [PDF]
Int J Mol Sci, 2022 Ramos H +4 more
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Salting-out induced liquid-liquid microextraction for alogliptin benzoate determination in human plasma by HPLC/UV. [PDF]
BMC Chem, 2021 Hammad SF +3 more
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