Results 31 to 40 of about 3,093 (146)

Lactiplantibacillus plantarum AS21 Attenuates Sex‐Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota‐Derived Citrulline

Aging Cell, Volume 25, Issue 8, August 2026.
Aging induces sex‐differential glucose intolerance, with male‐specific citrulline depletion. Lactiplantibacillus plantarum AS21 elevates microbiota‐derived citrulline metabolism and enhances GLP‐1 secretion, improving glucose homeostasis. ABSTRACT Aging‐related metabolic decline, particularly impaired glucose tolerance, represents a growing challenge ...
Mengya Jia, Mengyan Chen, Hu Chen, Huiling Zhang, Ruixue Dou, Chaorui Wang, Muhammad Ishaq, Xiaoying Wei, Zitong Ding, Xusheng Guo   +9 more
wiley   +1 more source

Bioequivalence Study of a New Generic Fixed-Dose Combination of Sitagliptin (100 mg) and Glimepiride (2 mg) in Healthy Adult Volunteers under Fasting Condition

Chronicle of Diabetes Research and Practice
Introduction: The present study evaluated the bioequivalence of a fixed-dose combination (FDC) of sitagliptin and glimepiride with the originator reference product.
Prashant Kumthekar, Mihir Upadhyay, Koripalli S. Reddy, Sambasiva R. Puram, Basava S. Nallamekala   +4 more
doaj   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, Volume 13, Issue 38, 9 July 2026.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia®)

Dermatology Online Journal, 2012
Photosensitivity to sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is reported. No previous reports of photosensitivity to any DPP-4 inhibitors are known. Physical examination of the patient revealed edematous plaques confined to sun-exposed areas of the skin.
Stricklin, Sherea M, Stoecker, William V, Rader, Ryan K, Hood, Antoinette F, Litt, Jerome Z, Schuman, Thomas P   +5 more
openaire   +4 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, Volume 13, Issue 38, 9 July 2026.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

An efficient RP-HPLC-based approach for simultaneous determination of sitagliptin and metformin HCl in pharmaceutical drug formulation

Pakistan Journal of Pharmaceutical Sciences
This study introduces an innovative, and rapid HPLC method using reverse phase elution for the simultaneous analysis of Sitagliptin and Metformin HCl in pharmaceutical formulations.
Mohsin Ali, Muhammad Raza Shah, Rustem Zairov, Shaista Zafar, Syed Imran Ali, Faizan Ansar, Khadim Mohi Uddin, Nurgali Akylbekov   +7 more
doaj   +1 more source

Efficacy and safety of sitagliptin added to metformin and insulin compared with voglibose in patients with newly diagnosed type 2 diabetes

Clinics, 2019
OBJECTIVE: To assess the efficacy and safety of sitagliptin compared with voglibose added to combined metformin and insulin in patients with newly diagnosed type 2 diabetes (T2DM).
Chunhong Shi, Ru Zhang, Ran Bai, Dan Liu, Yongbo Wang, Xueyang Zhang, Hao Wang, Jianling Du   +7 more
doaj   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Markers Predicting Cure With Combinatorial Treatment in a Mouse Model of Latent Autoimmune Diabetes in Adults

MedComm, Volume 7, Issue 7, July 2026.
This study explores a combinatorial treatment (CT) of GABA, sitagliptin, and omeprazole in a latent autoimmune diabetes in adults (LADA) mouse model. ∼30% of CT‐treated mice fully recovered, showing normoglycemia and insulin independence. Cell‐free RNA biomarkers Adgrb1 and Chd5 identify CT responders, aiding personalized treatment.
Wisal Sawaed, Ahmad Dallasheh, Sivan Eliyahu, Nura Aburomi, Aviad Sivan, Marina Kurtz, Michael Assa, Assaf Malka, Shira Perez, Ron Piran   +9 more
wiley   +1 more source

Assessment of cancer risk associated with 7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine‐contaminated sitagliptin use: A retrospective cohort study

Journal of Diabetes Investigation
Aims/Introduction A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7‐nitroso‐3‐(trifluoromethyl)‐5,6,7,8‐tetrahydro[1,2,4] triazolo‐[4,3‐a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its
Takehiro Sugiyama, Takashi Furuno, Yuichi Ichinose, Masao Iwagami, Noriko Ihana‐Sugiyama, Kenjiro Imai, Tamaki Kakuwa, Ryoko Rikitake, Mitsuru Ohsugi, Takahiro Higashi, Hiroyasu Iso, Kohjiro Ueki   +11 more
doaj   +1 more source