Practical Asymmetric Synthesis of Sitagliptin Phosphate Monohydrate [PDF]
Molecules, 2018 Optically pure sitagliptin phosphate monohydrate is efficiently and practically synthesized through a chiral hemiacetal as the key intermediate in 54% overall yield starting from (E)-4-(2,4,5-trifluorophenyl)but-2-enal and N-boc-protected hydroxylamine ...
Haoling Gao +3 more
doaj +7 more sources
Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization [PDF]
Frontiers in EndocrinologyAimTo investigate the effect and mechanism of Sitagliptin phosphate on inflammation and macrophage polarization in a mouse model of type 2 diabetes.MethodsIn vitro, Raw264.7 cells were cultured with a high concentration of glucose (HG) and sitagliptin ...
Xiaoxia Hu, Yalong Li, Xinyue Liu
doaj +8 more sources
Stability of extemporaneously prepared sitagliptin phosphate solution. [PDF]
PLoS ONE, 2022 Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used orally in conjunction with diet and exercise to control sugar levels in type 2 Diabetes Mellitus patients.
Abdel Naser Zaid +7 more
doaj +5 more sources
Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Phosphate Accelerates Cellular Cholesterol Efflux in THP-1 Cells [PDF]
Biomolecules, 2023 Cholesterol efflux is a major atheroprotective function of high-density lipoproteins (HDLs) which removes cholesterol from the foam cells of lipid-rich plaques in Type 2 diabetes.
Tomohiro Komatsu +7 more
doaj +3 more sources
Review of sitagliptin phosphate: a novel treatment for type 2 diabetes [PDF]
Vascular Health and Risk Management, 2007 Baptist GallwitzDept. Medicine IV, Eberhard Karls University, Tuebingen, GermanyAbstract: Sitagliptin (Januvia®, Merck Pharmaceuticals) is a dipeptidyl-peptidase inhibitor (DPP-4 inhibitor) that has recently been approved for the therapy of type 2 ...
Baptist Gallwitz
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Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model [PDF]
Scientific Reports, 2023 The solubility of an anti-hyperglycemic agent drug, (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4] triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine (also known as Sitagliptin phosphate) in supercritical carbon dioxide ...
Nedasadat Saadati Ardestani +4 more
doaj +4 more sources
Simultaneous Determination of Sitagliptin Phosphate Monohydrate and Metformin Hydrochloride in Tablets by a Validated UPLC Method [PDF]
Scientia Pharmaceutica, 2012 A novel approach was used to develop and validate a rapid, specific, accurate and precise reverse phase ultra performance liquid chromatographic (UPLC) method for the simultaneous determination of Sitagliptin phosphate monohydrate and Metformin hydrochloride in pharmaceutical dosage forms.
MALLESWARARAO, Chellu +2 more
exaly +4 more sources
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate [PDF]
Journal of Pharmaceutical Sciences, 2022 Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing ...
Tomokazu Tajiri +2 more
exaly +4 more sources
A Simple and Sensitive HPTLC Method for Simultaneous Determination of Metformin Hydrochloride and Sitagliptin Phosphate in Tablet Dosage Form [PDF]
Journal of Chemistry, 2013 A simple, rapid, and precise high-performance thin-layer chromatographic (HPTLC) method for simultaneous estimation of two antidiabetic drugs, metformin hydrochloride and sitagliptin phosphate, in tablet dosage form has been developed and validated ...
Darshana K. Modi +2 more
doaj +2 more sources
Two methods for the preparation of sitagliptin phosphate via chemical resolution and asymmetric hydrogenation [PDF]
RSC Advances, 2021 Two effective processes have been developed for the preparation of sitagliptin phosphate.
Fei Ye +5 more
openaire +4 more sources