Results 11 to 20 of about 3,093 (146)

Two methods for the preparation of sitagliptin phosphate via chemical resolution and asymmetric hydrogenation [PDF]

RSC Advances, 2021
Two effective processes have been developed for the preparation of sitagliptin phosphate.
Fei Ye, Zhifeng Zhang, Wenxia Zhao, Jianhai Ding, Yali Wang, Xueyan Dang   +5 more
openaire   +4 more sources

Sitagliptin, Metformin and Glimepiride Fixed‐Dose Combination Compared to Co‐Administration of Metformin and High‐Dose Glimepiride in Indian Patients With Type 2 Diabetes: A Randomised, Double‐Blind, Double‐Dummy, Phase 3 Clinical Study [PDF]

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6207-6216, July 2026.
ABSTRACT Aims This study assessed the efficacy and safety of a triple fixed‐dose combination (FDC) of sitagliptin, metformin, and glimepiride versus co‐administered metformin and glimepiride in Indian patients with uncontrolled Type 2 diabetes (T2D).
Rakesh Sahay, Ambanna Gowda, Manish Kumar Singh, A. Gopal Rao, Ramesh Duraisamy, Dinesh Gangwani, Jitendra Shukla, Vikas Agarwal, Sandesh Sahebarao Patil, Ambrish C., Satish Babu K. N., Arvind Palawat, Sandip Krishnrao Gofne, Abhay Kumar Sahoo, Pradeep Kumar Rai, Raisa Shaikh, Shruti Saha, Dipak Patil, Pravin Ghadge, Piyush Patel, Lalit Lakhwani, Suyog Mehta, Sadhna Joglekar   +22 more
wiley   +2 more sources

Improved Chromatographic Separation of Sitagliptin Phosphate and Metformin Hydrochloride [PDF]

International Journal of Biomedical Science, 2015
New UPLC method was developed for determination of sitagliptin and metformin using Symmetry C18 column (100 mm × 2.1 mm, 2.2 μm) and isocratic elution (methanol 20%), pH (3.5) as a mobile phase. The ultraviolet detector was operated at 220 nm and the column temperature was 50°C. Linearity parameters were acceptable over the concentration ranges of 2-12
Hendy MS.
openaire   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition [PDF]

Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +2 more sources

NiO/CuO@Graphene oxide-modified electrode for sensitive detection of an antidiabetic drug [PDF]

Scientific Reports
A new, simple, and cost-effective electrochemical sensor was developed for the determination of Sitagliptin phosphate monohydrate (SP) in powder, pharmaceutical tablet form and biological fluids as spiked plasma.
Essam N. Labeeb, Mahmoud A. Hefnawy, Shymaa S. Medany, Eman Yossri Frag   +3 more
doaj   +2 more sources

Differential Expression and Enzymatic Activity of DPPIV/CD26 Affects Migration Ability of Cervical Carcinoma Cells. [PDF]

PLoS ONE, 2015
Dipeptidyl peptidase IV (DPPIV/CD26) is a transmembrane glycoprotein that inactivates or degrades some bioactive peptides and chemokines. For this reason, it regulates cell proliferation, migration and adhesion, showing its role in cancer processes. This
Aline Beckenkamp, Júlia Biz Willig, Danielle Bertodo Santana, Jéssica Nascimento, Juliano Domiraci Paccez, Luiz Fernando Zerbini, Alessandra Nejar Bruno, Diogo André Pilger, Márcia Rosângela Wink, Andréia Buffon   +9 more
doaj   +1 more source

Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioequivalence Studies

Pharmaceutics, 2023
The purpose of this study is to derive an optimal drug release formulation with human clinical bioequivalence in developing a sitagliptin phosphate monohydrate-dapagliflozin propanediol hydrate fixed-dose combination (FDC) tablet as a treatment for type ...
So-Jin Kang, Joo-Eun Kim
doaj   +1 more source

Sitagliptin attenuates arterial calcification by downregulating oxidative stress-induced receptor for advanced glycation end products in LDLR knockout mice

Scientific Reports, 2021
Diabetes is a complex disease characterized by hyperglycemia, dyslipidemia, and insulin resistance. Plasma advanced glycation end products (AGEs) activated the receptor for advanced glycation end products (RAGE) and the activation of RAGE is implicated ...
Chih-Pei Lin, Po-Hsun Huang, Chi-Yu Chen, Meng-Yu Wu, Jia-Shiong Chen, Jaw-Wen Chen, Shing-Jong Lin   +6 more
doaj   +1 more source

Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study [PDF]

Diabetes & Metabolism Journal, 2019
BackgroundWe evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin.MethodsA total of 165 subjects were randomized to metformin ...
Hae Kyung Yang, Seung-Hwan Lee, Juyoung Shin, Yoon-Hee Choi, Yu-Bae Ahn, Byung-Wan Lee, Eun Jung Rhee, Kyung Wan Min, Kun-Ho Yoon   +8 more
doaj   +1 more source

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DPP-4 INHIBITOR, SITAGLIPTIN, IN ITS PHARMACEUTICAL PREPARATIONS

Eclética Química, 2018
A simple, sensitive and reproducible spectrophotometric method was developed for the determination of sitagliptin phosphate in bulk and in pharmaceutical formulations. The proposed method is based on condensation of the primary amino group of sitagliptin
C. Bala Sekaran, A. Prameela Rani
doaj   +1 more source