Results 41 to 50 of about 3,093 (146)

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, Volume 2, Issue 2, Page 236-279, June 2026.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Eco‐Friendly and Economical Approach for Immobilization of Thermostable ω‐Transaminase

Chemistry–Methods, Volume 6, Issue 5, May 2026.
This work presents immobilization of thermostable ω‐Transaminase on diatomaceous earth using eco‐friendly Fe3+‐tannic acid complexes. The immobilized enzyme retains optimal activity and preserves over half its activity after repeated cycles, offering a simple, economical immobilization strategy for industrial biocatalysis.
Wasia Khanam, Divya Gaur, Bijay P. Tripathi, Nidhi C. Dubey   +3 more
wiley   +1 more source

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou, Nikolaos Ktenopoulos, Anastasios Apostolos, Christos Fragoulis, Panayotis Vlachakis, Paschalis Karakasis, Marios Sagris, Nikias Milaras, Maria Drakopoulou, Andreas Synetos, Ioannis Kyriazis, Ioannis Ioannidis, Costas Tsioufis, Konstantinos Toutouzas   +13 more
wiley   +1 more source

Honey as a Natural Flavorful Product: A Comprehensive Review of Its Potential Biological Activities and Recent Studies

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Health impacts of honey. ABSTRACT Honey is a natural and nutritious product of the honey bee (Apis mellifera) with low water content. Its color ranges from white to amber, with taste varying accordingly. The chemical form and viscosity of honey depend on its composition.
Ecem Bolat, Ahmet Alperen Canbolat, Sümeyye Sarıtaş, Mauro Lombardo, Anna Maria Witkowska, Hesham El‐Seedi, Mikhael Bechelany, Sercan Karav   +7 more
wiley   +1 more source

Biocatalysis Under Reduced Pressure; Two‐Step, One‐Pot Amide Synthesis Using an Immobilised Transaminase/Lipase Cascade in Combination With By‐Product Removal

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
The application of biocatalytic cascades for organic synthesis can be encouraged through the use of easy‐to‐handle, immobilised enzymes and common laboratory equipment. We present a sequential biocatalytic cascade reaction that couples a transaminase (ATA) with a lipase, and achieves high conversion and enantioselectivity through by‐product removal ...
Lisa Kennedy, Nicholas Mulholland, Andrew Gomm, Dominic J. Campopiano   +3 more
wiley   +1 more source

Muscle Dysfunction and Bone Loss in a Woman With Cystic Fibrosis and Obesity Treated With Glucagon‐Like Peptide 1 Agonist: A Case Report

Respirology Case Reports, Volume 14, Issue 3, March 2026.
Cystic fibrosis (CF) modulator therapies can lead to rapid and excessive weight gain. Obesity in CF can lead to undesirable metabolic complications including type 2 diabetes. Therefore, glucagon‐like peptide 1 (GLP‐1) agonists which can facilitate weight loss and improve metabolic profiles are increasingly prescribed to people with CF.
Shanal Kumar, Robyn Cobb, Angela Matson, Joseph Lee, Daniel Henderson   +4 more
wiley   +1 more source

The potential effects of metformin and/or sitagliptin on leptin/adiponectin ratio in diabetic obese patients: a new therapeutic effect

Journal of the Pakistan Medical Association
Objective: To explore how metformin, alone or in conjunction with sitagliptin, affects the leptin/adiponectin ratio in obese type 2 diabetes mellitus patients.
Hala Aqeel Shams, Hussein Mohammed Aziz, Hayder Mutter Al-Kuraishy   +2 more
doaj   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus

Molecular Nutrition &Food Research, Volume 70, Issue 4, 26 February 2026.
This study elucidates the potential link between disulfidptosis and type 2 diabetes mellitus (T2DM). We propose that high SLC7A11 expression combined with glucose starvation triggers rapid NADPH depletion and severe disulfide stress. This leads to aberrant disulfide cross‐linking of actin cytoskeletal proteins and F‐actin network collapse, inducing ...
Danqi Zou, Yanping Zou, Yujie Jin, Shilin Liu, Minghao Lin, Ruixue Deng, Zheng Nan   +6 more
wiley   +1 more source