Results 41 to 50 of about 3,073 (139)

Muscle Dysfunction and Bone Loss in a Woman With Cystic Fibrosis and Obesity Treated With Glucagon‐Like Peptide 1 Agonist: A Case Report

Respirology Case Reports, Volume 14, Issue 3, March 2026.
Cystic fibrosis (CF) modulator therapies can lead to rapid and excessive weight gain. Obesity in CF can lead to undesirable metabolic complications including type 2 diabetes. Therefore, glucagon‐like peptide 1 (GLP‐1) agonists which can facilitate weight loss and improve metabolic profiles are increasingly prescribed to people with CF.
Shanal Kumar, Robyn Cobb, Angela Matson, Joseph Lee, Daniel Henderson   +4 more
wiley   +1 more source

The potential effects of metformin and/or sitagliptin on leptin/adiponectin ratio in diabetic obese patients: a new therapeutic effect

Journal of the Pakistan Medical Association
Objective: To explore how metformin, alone or in conjunction with sitagliptin, affects the leptin/adiponectin ratio in obese type 2 diabetes mellitus patients.
Hala Aqeel Shams, Hussein Mohammed Aziz, Hayder Mutter Al-Kuraishy   +2 more
doaj   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus

Molecular Nutrition &Food Research, Volume 70, Issue 4, 26 February 2026.
This study elucidates the potential link between disulfidptosis and type 2 diabetes mellitus (T2DM). We propose that high SLC7A11 expression combined with glucose starvation triggers rapid NADPH depletion and severe disulfide stress. This leads to aberrant disulfide cross‐linking of actin cytoskeletal proteins and F‐actin network collapse, inducing ...
Danqi Zou, Yanping Zou, Yujie Jin, Shilin Liu, Minghao Lin, Ruixue Deng, Zheng Nan   +6 more
wiley   +1 more source

Investigating operational stability and causes of cofactor release in fold type I amine transaminase

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Amine transaminases (ATAs) are pyridoxal phosphate (PLP) dependent biocatalysts frequently employed in chiral amine synthesis. Yields of ATA‐catalyzed reactions often suffer from low enzyme operational stability due to weak interactions between the ATA and the aminated cofactor pyridoxamine phosphate (PMP), which can leak from the active site ...
Xuebin Feng, William Chau, Emma R. Master   +2 more
wiley   +1 more source

Stability indicating HPTLC method for simultaneous analysis of sitagliptin phosphate monohydrate and pioglitazone hydrochloride with greenness assessment using AGREE, ESA, BAGI and CACI

Discover Chemistry
A stability-indicating high-performance thin-layer chromatographic (HPTLC) method was developed for the simultaneous determination of sitagliptin phosphate monohydrate and pioglitazone hydrochloride in a combined antidiabetic mixture.
Riddhi B. Nagar, Rashmi Korat, Zarna Dedania, Vineet C. Jain, Ashok H. Akabari   +4 more
doaj   +1 more source

Protective Role of Linagliptin in Cisplatin‐Mediated Liver Injury: Involvement of STAT3 and AMPK/SIRT1/PGC‐1alpha Mitochondrial Energy Sensing Networks

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Cisplatin (Cis), a commonly used chemotherapy drug, is associated with liver toxicity, which restricts its broader clinical use. This study investigated the potential protective effects of linagliptin (Lina), a DPP‐4 inhibitor, in preventing liver damage induced by Cis in rats. There were four groups of male rats: a control group, a Cis group (8 mg/kg,
Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Yosra Assem Hussien, Zeinab A. El-Gendy, Sherif M. Afifi, Tuba Esatbeyoglu, Alyaa Farouk Hessin, Reda Korany M. S., Hany M. Fayed, Anjali Chauhan   +10 more
wiley   +1 more source

Yiqi–Wenyang–Tiaoshen Decoction Reduces Cisplatin‐Induced Acute Kidney Injury in Rats Through Autophagy and Apoptosis Signaling Pathways Based on Network Pharmacology and Experimental Validation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Context The mechanism of Yiqi–Wenyang–Tiaoshen decoction (YWT) in treating cisplatin‐induced acute kidney injury (AKI) remains unknown. Objective This study identifies the key components of YWT and explores its therapeutic potential and mechanisms in a cisplatin‐induced AKI rat model.
Yunqi Bai, Yue Chang, Lili Zhang, Wenjing Zhou, Yixin Su, Jingwei Zhou, Jingru Tian   +6 more
wiley   +1 more source

Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate‐Induced Liver Injury

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Methotrexate (MTX) is a widely used chemotherapeutic and immunosuppressive agent for treating various malignancies, autoimmune diseases (AIDs), and inflammatory disorders. Despite its therapeutic efficacy, long term or high‐dose MTX treatment is associated with a significant risk of hepatotoxicity, leading to MTX‐induced liver injury (MTX‐LI).
Bushra Zia, Mouza Hasan Alqaishi Alshehhi, Azimullah Sheikh, Samir Mirza, Sandeep B. Subramanya, Shreesh K. Ojha, Priya Gusain   +6 more
wiley   +1 more source

The SGLT2i “canagliflozin” and the DPP-4i “sitagliptin” mitigate hypertensive nephropathy in adult male rats by modulating the Ang II/RAGE/Nox4/NLRP3 cascade

Frontiers in Physiology
BackgroundHypertensive nephropathy (HN) with progressive renal damage is a common consequence of arterial hypertension (HTN). This study addresses the renoprotective attributes of the sodium-glucose cotransporter-2 inhibitor canagliflozin (Cana) and the ...
Fatma E. Hassan, Fatma E. Hassan, Fatma Al-Zahraa Nabil Al-Shahed, Asmaa Selmy, Lamiaa Mohamed Mahmoud, Basant A. Aldreny   +5 more
doaj   +1 more source