Results 51 to 60 of about 3,093 (146)

Investigating operational stability and causes of cofactor release in fold type I amine transaminase

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Amine transaminases (ATAs) are pyridoxal phosphate (PLP) dependent biocatalysts frequently employed in chiral amine synthesis. Yields of ATA‐catalyzed reactions often suffer from low enzyme operational stability due to weak interactions between the ATA and the aminated cofactor pyridoxamine phosphate (PMP), which can leak from the active site ...
Xuebin Feng, William Chau, Emma R. Master   +2 more
wiley   +1 more source

Stability indicating HPTLC method for simultaneous analysis of sitagliptin phosphate monohydrate and pioglitazone hydrochloride with greenness assessment using AGREE, ESA, BAGI and CACI

Discover Chemistry
A stability-indicating high-performance thin-layer chromatographic (HPTLC) method was developed for the simultaneous determination of sitagliptin phosphate monohydrate and pioglitazone hydrochloride in a combined antidiabetic mixture.
Riddhi B. Nagar, Rashmi Korat, Zarna Dedania, Vineet C. Jain, Ashok H. Akabari   +4 more
doaj   +1 more source

Protective Role of Linagliptin in Cisplatin‐Mediated Liver Injury: Involvement of STAT3 and AMPK/SIRT1/PGC‐1alpha Mitochondrial Energy Sensing Networks

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Cisplatin (Cis), a commonly used chemotherapy drug, is associated with liver toxicity, which restricts its broader clinical use. This study investigated the potential protective effects of linagliptin (Lina), a DPP‐4 inhibitor, in preventing liver damage induced by Cis in rats. There were four groups of male rats: a control group, a Cis group (8 mg/kg,
Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Yosra Assem Hussien, Zeinab A. El-Gendy, Sherif M. Afifi, Tuba Esatbeyoglu, Alyaa Farouk Hessin, Reda Korany M. S., Hany M. Fayed, Anjali Chauhan   +10 more
wiley   +1 more source

Novel chemometric-driven greenness assessed spectroscopical method development and forced degradation study of sitagliptin phosphate in its bulk drug and ophthalmic formulation

Journal of Applied Pharmaceutical Research
Background: Sitagliptin phosphate (SIT), an antidiabetic drug, requires reliable analytical methods for routine quality control and stability assessment. UV-visible spectrophotometry offers a simple and economical approach; however, method robustness and
Debashis Mishra, Himansu Bhusan Samal, Diptimayee Jena, Kirtimaya Mishra   +3 more
doaj   +1 more source

Pharmacokinetics and Bioequivalence of Sitagliptin Phosphate/Metformin Hydrochloride Tablets in Healthy Chinese Subjects: A Randomized, Open-Label, Crossover Study. [PDF]

Drugs R D, 2022
Shi P, Liu X, Li T, Sun FF, Liu YP, Liu SQ, Gao XM, Ma YP, Fu Y, Cao Y.   +9 more
europepmc   +1 more source

Development and Validation of RP-HPLC Method for the Estimation of Sitagliptin Phosphate in Tablet Dosage Form

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH, 2017
A new simple, rapid, specific, accurate, precise and novel Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the estimation of Sitagliptin Phosphate in the pharmaceutical dosage form. The chromatographic separation for Sitagliptin was achieved with mobile phase containing methanol, Thermoscientific C18 column,
D, Sireesha, E, Sai Lakshmi, E, Sravya, Bakshi, Vasudha   +3 more
openaire   +4 more sources

The SGLT2i “canagliflozin” and the DPP-4i “sitagliptin” mitigate hypertensive nephropathy in adult male rats by modulating the Ang II/RAGE/Nox4/NLRP3 cascade

Frontiers in Physiology
BackgroundHypertensive nephropathy (HN) with progressive renal damage is a common consequence of arterial hypertension (HTN). This study addresses the renoprotective attributes of the sodium-glucose cotransporter-2 inhibitor canagliflozin (Cana) and the ...
Fatma E. Hassan, Fatma E. Hassan, Fatma Al-Zahraa Nabil Al-Shahed, Asmaa Selmy, Lamiaa Mohamed Mahmoud, Basant A. Aldreny   +5 more
doaj   +1 more source

Sitagliptin phosphate [PDF]

, 2020
openaire   +3 more sources

Beyond glycemic control: differential effects of empagliflozin and sitagliptin on insulin sensitivity and a shared increase in adropin in type 2 diabetes

BMC Endocrine Disorders
Background Type 2 diabetes mellitus (T2DM) is characterized by metabolic and inflammatory disturbances beyond hyperglycemia. Hepatokines such as adropin have emerged as regulators of insulin resistance and vascular function, yet the comparative metabolic
Otbah Salim Taha, Golnaz Azami, Lotfollah Saed, Mohammad Saeed Hakhamaneshi, Heresh Moridi   +4 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source