Results 21 to 30 of about 23,280 (257)
Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes
Diabetes, Metabolic Syndrome and Obesity, 2009 Jonathan K ReynoldsWashington State University, College of Pharmacy, Pullman, WA, USAAbstract: JanumetTM, a fixed dose combination of sitagliptin/metformin HCL manufactured by Merck Pharmaceuticals, has received US Food and Drug Administration approval ...
Jonathan K Reynolds
doaj +1 more source
Genetic Study on the Effect of the Antidiabetic Drug (Sitagliptin) on DNA and Chromosomes of Human Lymphocyte Culture [PDF]
The Egyptian Journal of Histology, 2021 Background: Diabetes mellitus is a worsening worldwide health problem. It constitutes a major global health concern. Sitagliptin selectively inhibits dipeptidyl peptidase-4 (DPP-4) to manage type 2 diabetes mellitus (T2DM). It regulates the blood glucose
Rania Yassien +4 more
doaj +1 more source
Pakistan Journal of Pharmaceutical Sciences, 2023 Pharmaceutical substance sitagliptin has long been used to treat diabetes. However, subsequent researches have shown that sitagliptin has additional therapeutic effects. Anti-inflammatory effects are observed.
Muhammad Abdullah +6 more
doaj +1 more source
Experimed, 2023 Objective: Impairment of immune cell signaling molecules is involved in diseases pathogenesis. The evaluation of signal transducer and activator of transcription (STAT) 4 and protein inhibitor of activated STAT (PIAS) 2 as well as immunoregulatory role ...
Sina Nabiyi +3 more
doaj +1 more source
Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats [PDF]
PeerJ, 2020 Increasing evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. We hypothesized that maternal sitagliptin intervention may improve glucose intolerance through gut targeting. Female Sprague-Dawley (SD) rats were fed a
Qian Zhang +7 more
doaj +2 more sources
The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Fatty liver disease (FLD) is a disorder related to accumulation of excess fat within the hepatocytes. In this study, the effects of Berberine, a natural compound, and Sitagliptin as a DPP-4 inhibitor, were observed in a rat model of FLD ...
Soraya Mehrdoost +3 more
doaj +1 more source
Identification of sitagliptin binding proteins by affinity purification mass spectrometry
Acta Biochimica et Biophysica Sinica, 2022 Type 2 diabetes mellitus (T2DM) is recognized as a serious public health concern with increasing incidence. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin has been used for the treatment of T2DM worldwide.
Wang Xue-Ning +12 more
doaj +1 more source
Cell Death and Disease, 2021 Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT) is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its mechanism of action in SAP-ALI remains unclear.
Ling-Ming Kong +7 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2023 Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus. This study examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on DN and explored the underlying mechanism.
Sarah M. AL-Qabbaa +10 more
semanticscholar +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 The standard regimen treatment has improved GBM outcomes, but the survival rate of patients is still unsatisfactory. Temozolomide (TMZ) resistance is one of main reasons limiting the therapeutic efficacy of GBM.
Fang You +9 more
semanticscholar +1 more source