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Dipeptidyl peptidase-4 inhibitors
Reactions Weekly, 2021The dipeptidyl peptidase 4 (DPP-4) inhibitor has become a popular anti-diabetes medication since its introduction in 2006. They are small molecules that specifically bind to the catalytic domain of DPP-4, which consequently prevents the enzymatic inactivation of incretin hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide)
Yoo Hyung Kim, Young Min Cho
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Highlight: Dipeptidyl peptidase 4 and related proteins
Biological Chemistry, 2011No abstract ...
Torsten, Hoffmann, Hans-Ulrich, Demuth
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Renal outcomes with dipeptidyl peptidase-4 inhibitors
Diabetes & Metabolism, 2018Dipeptidyl peptidase-4 inhibitors (DPP-4is) are increasingly being used in the management of type 2 diabetes (T2D). The present review summarizes the current knowledge of the effects of DPP-4is on renal outcomes by analyzing the experimental preclinical data, the effects of DPP-4is on urinary albumin-creatinine ratios (UACRs) and estimated glomerular ...
Scheen, André, DELANAYE, Pierre
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Pharmacology of Dipeptidyl Peptidase-4 Inhibitors
Drugs, 2011The dipeptidyl peptidase (DPP)-4 inhibitors, which enhance glucose-dependent insulin secretion from pancreatic β cells by preventing DPP-4-mediated degradation of endogenously released incretin hormones, represent a new therapeutic approach to the management of type 2 diabetes mellitus. The 'first-in-class' DPP-4 inhibitor, sitagliptin, was approved in
R. Baetta, A. Corsini
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Dipeptidyl-Peptidase 4 (DPP4) Inhibitors
Highlights: Introduction Pharmacology Treatment Advantages/Disadvantages Therapeutic Considerations Monographs ...Kimberly C. McKeirnan +1 more
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Dipeptidyl peptidase-4 inhibitors
2016Dipeptidyl peptidase (DPP)-4 inhibitors inhibit the activity of the enzyme responsible for the initial rapid degradation of the incretin hormones, thereby enhancing their antihyperglycemic effects.
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Dipeptidyl Peptidase-4 A Comprehensive Review
Current Enzyme InhibitionAbstract: Type 2 diabetes mellitus is a growing global public health issue, with its prevalence projected to increase in the coming decades. It is one of the most prevalent and growing global health concerns, affecting millions of individuals worldwide.
V. Parthasarathi, Hemalatha K.
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Periostin and Dipeptidyl Peptidase-4
Immunology and Allergy Clinics of North America, 2018Claire Emson +3 more
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