Results 21 to 30 of about 49,828 (259)

The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum [PDF]

, 2004
The discovery of a potentially novel proline-specific peptidase from bovine serum is presented which is capable of cleaving the dipeptidyl peptidase IV (DPIV) substrate Gly-Pro-MCA.
Buckley, Seamus J., O'Connor, Brendan, O\u27Connor, Brendan, Collins, Patrick   +3 more
core   +1 more source

SARS-CoV-2 and diabetes: A potential therapeutic effect of dipeptidyl peptidase 4 inhibitors in diabetic patients diagnosed with COVID-19

Metabolism Open, 2021
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 and has become an urgent economic and health challenge. Dipeptidyl peptidase 4 (DPP4), also mentioned as a cluster of differentiation 26 (CD26) is a serine exopeptidase found in two ...
Zemene Demelash Kifle, Alem Endeshaw Woldeyohanin, Chilot Abiyu Demeke   +2 more
doaj   +1 more source

Solvent and thermal stability, and pH kinetics, of proline-specific dipeptidyl peptidase IV-like enzyme from bovine serum [PDF]

, 2007
Proline-specific dipeptidyl peptidase-like (DPP IV; EC 3.4.14.5) activity in bovine serum has attracted little attention despite its ready availability and the paucity of useful proline-cleaving enzymes.
Ruth, Deborah M., Buckley, Seamus J., Ó Fágáin, Ciarán, O'Connor, Brendan, O\u27Connor, Brendan   +4 more
core   +1 more source

Sulfated galactofucan from seaweed Padina tetrastromatica attenuates proteolytic enzyme dipeptidyl-peptidase-4: a potential anti-hyperglycemic lead

, 2022
Dipeptidyl-peptidase-4 is a multifunctional ectoenzyme, which is implicated with hyperglycemic pathophysiology. Therefore, dipeptidyl-peptidase-4 inhibitors could be used as an attractive therapeutic strategy in blood-glucose homeostasis to attenuate the
Kajal Chakraborty (2629708), Tima Antony (6480827), Shubhajit Dhara (6425897)   +2 more
core   +1 more source

Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors [PDF]

Diabetes & Metabolism Journal, 2022
Background It is not known which type 2 diabetes mellitus (T2DM) patients would most benefit from dipeptidyl peptidase-4 (DPP-4) inhibitor treatment.
Sangmo Hong, Chang Hee Jung, Song Han, Cheol-Young Park   +3 more
doaj   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +1 more source

Comparing treatment intensification and clinical outcomes of metformin and dipeptidyl peptidase‐4 inhibitors in treatment‐naïve patients with type 2 diabetes in Japan

Journal of Diabetes Investigation, 2020
Japan's guidelines emphasize tailored therapy, but do not guide physicians on the use of a specific regimen in drug‐naive patients. The role of long‐term initial therapy could be important in key elements of diabetes treatment, such as continuation of ...
Takeshi Horii, Makiko Iwasawa, Jyunichi Shimizu, Koichiro Atsuda   +3 more
doaj   +1 more source

DPP4 (dipeptidyl-peptidase 4) [PDF]

, 2013
Review on DPP4 (dipeptidyl-peptidase 4), with data on DNA, on the protein encoded, and where the gene is ...
Morimoto, C, Ohnuma, K
core   +1 more source

Multiple-Peptidase Mutants of Lactococcus lactis Are Severely Impaired in Their Ability To Grow in Milk [PDF]

, 1996
To examine the contribution of peptidases to the growth of Lactococcus lactis in milk, 16 single- and multiple-deletion mutants were constructed. In successive rounds of chromosomal gene replacement mutagenesis, up to all five of the following peptidase ...
Konings, Wil N., Poolman, Bert,, Venema, Gerard,, Haandrikman, Alfred J.,, Konings, Wil N.,, Kok, Jan, Mierau, I, Hellendoorn, Michiel A.,, Kunji, E.R S, Hellendoorn, Michiel A., Mierau, Igor, Leenhouts, Kees J., Kunji, Edmund R.S.,, Kok, J., Poolman, Bert, Venema, Gerard, Mierau, Igor,, Poolman, B., Kok, Jan,, Leenhouts, Kees J.,, Kunji, Edmund R.S., Konings, W.N, Haandrikman, Alfred J., Venema, G   +23 more
core   +1 more source

An updated systematic review and meta-analysis on the efficacy and tolerability of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes with moderate to severe chronic kidney disease

SAGE Open Medicine, 2016
Objective: This updated meta-analysis determines the effect of dipeptidyl peptidase-4 inhibitors on glycemic and tolerability outcomes in patients with type 2 diabetes mellitus and chronic kidney disease with glomerular filtration rate of ⩽60 mL/min or ...
Devada Singh-Franco, Catherine Harrington, Eglis Tellez-Corrales   +2 more
doaj   +1 more source