Results 171 to 180 of about 41,710 (302)

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

open access: yesComprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková   +5 more
wiley   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

open access: yesMicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq   +2 more
wiley   +1 more source

Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor. [PDF]

open access: yesIntern Med, 2022
Takedomi H   +9 more
europepmc   +1 more source

Phytotherapeutic Regulation of Matrix Metalloproteinases in Diabetic Foot Ulcer: Molecular Mechanisms and Wound Healing Perspectives

open access: yesPhytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Chronic inflammation in diabetic foot ulcers elevates MMP activity and suppresses TIMP and growth factor signaling, impairing tissue repair. Phytochemicals modulate NF‐κB/MAPK pathways and enhance Nrf2–TIMP expression, restoring MMP/TIMP balance, promoting collagen deposition, angiogenesis, and re‐epithelialization, leading to effective wound healing ...
Vishnu Priyan Elaiyaraja   +3 more
wiley   +1 more source

Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Phosphate Accelerates Cellular Cholesterol Efflux in THP-1 Cells. [PDF]

open access: yesBiomolecules, 2023
Komatsu T   +7 more
europepmc   +1 more source

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