Results 181 to 190 of about 115,987 (377)

Effect of preoperative SGLT2 inhibitor use on postoperative acute kidney injury in patients with type 2 diabetes undergoing surgery: A causal inference study using routinely collected data

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To assess whether preoperative sodium‐glucose co‐transporter 2 inhibitor (SGLT2i) use reduces the odds of postoperative acute kidney injury (AKI) in patients with type 2 diabetes undergoing surgery. Methods We conducted a target trial emulation using inverse probability of treatment weighting, utilising routinely collected data from a ...
Frank M. Gao, Kartik Kishore, Dinesh Pandey, Hossein Jahanabadi, Meg Stevens, Ashani Lecamwasam, Leonid Churilov, Elif I. Ekinci   +7 more
wiley   +1 more source

Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors

Nature Communications
Covalent chemical probes and drugs combine unique pharmacologic properties with the availability of straightforward compound profiling technologies via chemoproteomic platforms.
Leonard Sewald, Werner W. A. Tabak, Lorenz Fehr, Samuel Zolg, Maja Najdzion, Carlo J. A. Verhoef, David Podlesainski, Ruth Geiss-Friedlander, Alfred Lammens, Farnusch Kaschani, Doris Hellerschmied, Robert Huber, Markus Kaiser   +12 more
doaj   +1 more source

Seizure recurrence after GLP‐1 receptor agonist initiation in adults with epilepsy

Epilepsia, EarlyView.
Abstract Objective To examine whether initiation of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabetes. Methods We conducted a retrospective cohort study using de‐identified electronic health records from the TriNetX Research Network (January 2003 ...
Majd A. AbuAlrob, Abdullah Hussein, Rand Abdellatif, Adham Itbaisha, Khaled Zammar, Boulenouar Mesraoua   +5 more
wiley   +1 more source

The clinical effectiveness of sodium-glucose co-transporter-2 inhibitors on prognosis of patients with chronic obstructive pulmonary disease and diabetes

Nature Communications
Diabetes is common in patients with chronic obstructive pulmonary disease. Sodium-glucose co-transporter-2 inhibitors are effective in treating type 2 diabetes and provide benefits for conditions like cardiovascular and kidney diseases.
Jheng-Yan Wu, Khai-Chi Hu, Mei-Yuan Liu, Yu-Jou Wu, Wan-Hsuan Hsu, Ya-Wen Tsai, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Tsung Yu, Kuang-Ming Liao, Chih-Cheng Lai   +11 more
doaj   +1 more source

Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice [PDF]

, 2021
Cayasso, Mayella, László, F. János, Pórszász, Róbert, Szalai, Andrea, Ujhelyi, Judit Ágnes, Ujhelyi, Zoltán, Vecsernyés, Miklós   +6 more
core   +1 more source

WONOEP XVII appraisal: The immunopathogenesis of epilepsy

Epilepsia, EarlyView.
Abstract There is a wealth of data indicating that the immune system plays an important role in seizure disorders. This includes autoimmune encephalitis, in which an immune response directed against neuronal antigens results in brain inflammation and subsequent seizure activity, as well as autoimmune‐associated epilepsy and neuroinflammatory changes ...
Nihan Çarçak, Said Al Maawal, Peravina Thergarajan, Tracie H. L. Tan, Vinod Kumar Mehta, Tamara Baker, David C. Henshall, Aristea S. Galanopoulou, Özlem Akman, Pablo M. Casillas‐Espinosa, Raman Sankar, Laura Librizzi, Adam E. Handel   +12 more
wiley   +1 more source

Review for "Lower Cardiorenal Risk with Sodium-Glucose Cotransporter-2 Inhibitors versus Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Patients without Cardiovascular and Renal Diseases: A large multinational observational study"

, 2020

openalex   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, EarlyView.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Dipeptidyl Peptidase 9 [PDF]

, 2020
openaire   +1 more source

Studi Qsar Senyawa Turunan Triazolopiperazin Amida sebagai Inhibitor Enzim Dipeptidil Peptidase-IV (DPP IV) Menggunakan Metode Semiempirik AM1 [PDF]

, 2013
Studi QSAR (Quatitative Structure-Activity Relationship) telah dilakukan untuk senyawa turunan triazolopiperazin amida sebagai inhibitor enzim DPP IV (dipeptidil peptidase-IV) yang merupakan penyebab diabetes melitus tipe 2.
Asmara, A. P. (Anjar), Mudasir, M. (Mudasir), Siswanta, D. (Dwi)   +2 more
core