Results 191 to 200 of about 115,987 (377)

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, EarlyView.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source

Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases [PDF]

, 2018
Fandi Kong, Xiaoyan Pang, Jihui Zhao, Pan Deng, Mingyue Zheng, Dafang Zhong, Xiaoyan Chen   +6 more
openalex   +1 more source

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer [PDF]

, 2023
Bei Zuo, Tao Li, Xiaoyun Liu, Shuling Wang, Jianxiang Cheng, Xiangqun Liu, Wenjie Cui, Hengliang Shi, Chunhua Ling   +8 more
openalex   +1 more source

Effect of switching from intermittently scanned continuous glucose monitoring to FreeStyle Libre 2 with real‐time continuous glucose monitoring and alert functionality

Journal of Diabetes Investigation, EarlyView.
Transitioning from FSL to FSL2 with rtCGM function improved sensor usage and glycemic control, particularly in patients with Type 1 diabetes. The duration required for improvement in continuous glucose monitoring‐related parameters varied by diabetes type, with early improvements observed in Type 1 diabetes and gradual improvements in Type 2 diabetes ...
Keiji Sugai, Junko Sasaki, Gakuyuki Tomizawa, Ryo Suzuki   +3 more
wiley   +1 more source

Dipeptidyl Peptidase Inhibitors and Transdermal Approach in Type 2 Diabetes Mellitus Treatment: Traditional Review [PDF]

Zeynep CEMEK, Sevınç Şahbaz
openalex   +1 more source

Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4 [PDF]

, 2019
Po-Kai Huang, Shian‐Ren Lin, Jirawat Riyaphan, Yaw‐Syan Fu, Ching‐Feng Weng   +4 more
openalex   +1 more source

Efficacy of probiotics (Bifidobacterium bifidum G9‐1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open‐label, single‐arm study (BIRDIE study)

Journal of Diabetes Investigation, EarlyView.
Bifidobacterium bifidum G9‐1 improved stool form, defecation frequency, and Quality of Life in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation. ABSTRACT Introduction Although constipation is a major complication of type 2 diabetes mellitus and chronic kidney disease, evidence for its treatment in these ...
Fuki Ikeda, Junko Sato, Hidenori Yoshii, Masahiro Sugawara, Hiroaki Satoh, Yukiko Sugawara, Hirotsugu Uzawa, Daisuke Sugimoto, Reina Muto, Yuya Nishida, Hirotaka Watada   +10 more
wiley   +1 more source

Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice

Journal of Diabetes Investigation, EarlyView.
This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto, Sodai Kubota, Hiromi Tsuchida, Yanyan Liu, Seiya Banno, Toshinori Imaizumi, Taro Fujisawa, Yoshihiro Takahashi, Takehiro Kato, Yukio Horikawa, Katsumi Iizuka, Takaaki Murakami, Yuuka Fujiwara, Hitoshi Kuwata, Yuji Yamazaki, Yutaka Seino, Shin Tsunekawa, Daisuke Yabe   +17 more
wiley   +1 more source

Serum and Salivary Estimation of Dipeptidyl Peptidase IV, as a Prognostic Indicator in Oral Squamous Cell Carcinoma before and during Radiotherapy

Journal of Indian Academy of Oral Medicine and Radiology, 2010
Increase in serum and salivary levels of Dipeptidyl peptidase IV (DPP IV) was reported earlier in the patients of oral squamous cell carcinoma. A study was conducted in the department to assess, the serum and salivary levels of Dipeptidyl peptidase IV in
Pranoti Pradhan, Anil Ghom, R N Mody
doaj  

The In Vitro Inhibitory Activity of Pacaya Palm Rachis versus Dipeptidyl Peptidase-IV, Angiotensin-Converting Enzyme, α-Glucosidase and α-Amylase [PDF]

Aurea Bernardino‐Nicanor, Stephanie Fernández-Avalos, José Mayolo Simitrio Juárez-Goiz, José Luis Montañez-Soto, Leopoldo González-Cruz   +4 more
openalex   +1 more source