Results 281 to 290 of about 115,987 (377)

A phase 1 single and multiple ascending dose study of orforglipron in Japanese participants with type 2 diabetes

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 2, Page 205-213, February 2026.
Orforglipron, a novel oral non‐peptide GLP‐1 receptor agonist, was evaluated in a Phase 1, double‐blind, placebo‐controlled, randomized, single and multiple ascending dose study in Japanese participants with type 2 diabetes. The safety and tolerability profile of orforglipron was consistent with those of other GLP‐1 receptor agonists, and ...
Kenji Ohwaki   +4 more
wiley   +1 more source

Cardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors.

open access: yesJAMA Netw Open
Turchin A   +12 more
europepmc   +1 more source

Diabetic peripheral neuropathy as measured using a point‐of‐care sural nerve conduction device is associated with a faster decline in renal function in patients with type 2 diabetes

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 2, Page 291-300, February 2026.
Point‐of‐care assessment of diabetic peripheral neuropathy with DPN‐Check® was independently associated with a faster decline in renal function in type 2 diabetes, highlighting its potential as a tool to identify patients at high risk of kidney disease progression. ABSTRACT Aims/Introduction Diabetic peripheral neuropathy (DPN) is a common complication
Tatsuya Fukuda   +5 more
wiley   +1 more source

The difference in type 2 diabetes care between the National Health Insurance beneficiaries and public assistance recipients in Japan: A retrospective cohort study based on claims data in a municipality

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 2, Page 347-359, February 2026.
We examined the differences in type 2 diabetes care between public assistance recipients and National Health Insurance beneficiaries in Japan by using claims data from a municipality. Public assistance might improve diabetes care process, but not fully health outcomes.
Takuya Yamaoka   +4 more
wiley   +1 more source

Association of urinary dipeptidyl peptidase 4 activity with clinical outcomes in people with chronic kidney disease. [PDF]

open access: yesSci Rep
Benetti A   +7 more
europepmc   +1 more source

Predictors of glycemic control with imeglimin for type 2 diabetes: Results of machine learning analyses using clinical trial data

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 2, Page 214-226, February 2026.
Identifying patient characteristics predictive of treatment response is crucial for optimizing type 2 diabetes outcomes. Using data from three phase 2/3 imeglimin trials in Japan, this analysis applied machine learning to determine characteristics associated with HbA1c improvement.
Katsuhiko Hagi   +4 more
wiley   +1 more source

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