Results 201 to 210 of about 20,669 (341)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis. [PDF]

Chembiochem
Kuge M, Keppler M, Friedrich F, Saleem-Batcha R, Winter J, Prucker I, Germer P, Gerhardt S, Einsle O, Jung M, Jessen HJ, Andexer JN.   +11 more
europepmc   +1 more source

Engineered geranyl diphosphate methyltransferase produces 2-methyl-dimethylallyl diphosphate as a noncanonical C₆ unit for terpenoid biosynthesis. [PDF]

Synth Syst Biotechnol, 2023
Xia CY, Lu BW, Cui JY, Wang BY, Sun YY, Gan F.   +5 more
europepmc   +1 more source

Examining the Impact of Diet‐and‐Exercise‐Induced Weight Loss on Drug Metabolism and Gastric Emptying in Patients with Obesity

The Journal of Clinical Pharmacology, EarlyView.
Abstract Obesity significantly influences drug pharmacokinetics (PK), which challenges optimal dosing. This study examines the effects of diet‐and‐exercise‐induced weight loss on key drug‐metabolizing enzymes and gastric emptying in patients with obesity, who frequently require medications for comorbidities.
Shuhan Liu, Lu Wang, Nicole Miller, Andrea Waltje, Mohamed Abdelnabi, Hao‐Jie Zhu, Duxin Sun, Amy E. Rothberg, Manjunath P. Pai   +8 more
wiley   +1 more source

Exploring and expanding the natural chemical space of bacterial diterpenes. [PDF]

Nat Commun
Wei X, Ning W, McCadden CA, Alsup TA, Li Z, Łomowska-Keehner DP, Nafie J, Qu T, Opoku MO, Gillia GR, Xu B, Icenhour DG, Rudolf JD.   +12 more
europepmc   +1 more source

Effects of inorganic ions and of plasma proteins on the aggregation of blood platelets by adenosine diphosphate [PDF]

, 1964
G. V. R. Born, Michael Cross
openalex   +1 more source

In Vitro and Clinical Evaluations of UGT1A1‐, P‐gp‐, OATP1B1‐, and BCRP‐Mediated Drug–Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor

The Journal of Clinical Pharmacology, EarlyView.
Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi   +4 more
wiley   +1 more source

Structure-function insights into the dual role of African swine fever virus pB318L: A typical geranylgeranyl-diphosphate synthase and a nuclear import protein. [PDF]

Virol Sin
Zhao HF, Wang Y, Liu XH, Liu XH, Geng Z, Gao ZQ, Huang L, Weng CJ, Dong YH, Zhang H.   +9 more
europepmc   +1 more source

GLYCOGEN SYNTHESIS FROM URIDINE DIPHOSPHATE GLUCOSE [PDF]

, 1961
David Luck
openalex   +1 more source

Thymidine diphosphate mannose and thymidine diphosphate rhamnose in Streptomyces grieus [PDF]

Biochemical Journal, 1961
J. Baddiley, N. L. Blumsom
openaire   +3 more sources