Results 201 to 210 of about 542,716 (249)
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2000
Abstract Diphtheria toxin (DTX) is a polypeptide of approximately 60 kDa secreted by the bacterium Corynebacterium diphtheriae, a gram-positive nonsporulating rod. Infection with the bacterium in the nasopharynx and subsequent release of toxin into the circulation accounts for the local and systemic manifestations of diphtheria, a ...
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Abstract Diphtheria toxin (DTX) is a polypeptide of approximately 60 kDa secreted by the bacterium Corynebacterium diphtheriae, a gram-positive nonsporulating rod. Infection with the bacterium in the nasopharynx and subsequent release of toxin into the circulation accounts for the local and systemic manifestations of diphtheria, a ...
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Diphtheria Toxin Fusion Proteins
1998Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
F M, Foss +4 more
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Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain
Biochemical and Biophysical Research Communications, 1982Abstract Inositol hexaphosphate, and other polyphosphates, inhibit diphtheria toxin-mediated cytotoxicity by binding to the toxin at a highly cationic site called the P site and preventing toxin binding to cell surface receptors. The binding of diphtheria toxin to a solubilized cell surface glycoprotein (150,000 daltons) is also inhibited by these ...
L, Eidels, L L, Ross, D A, Hart
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Iron and Diphtheria Toxin Production
1975The extreme sensitivity of diphtheria toxin production to the iron concentration of the medium was clearly shown by Pappenheimer and Johnson [1]. Iron level of the medium, therefore, has to be carefully controlled whether diphtheria toxin is produced using a surface or a submerged culture.
S V, Gadre, S S, Rao
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Nature, 1968
ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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The Diphtheria Toxin Structural Gene
1985While there was considerable indirect evidence that toxinogenesis in Corynebacterium diphtheria was related to lysogeny (FREEMAN 1951; FREEMAN AND MORSE 1952; GROMAN 1953 a, b, 1955; GROMAN and EATON 1955; HOLMES and BARKSDALE 1969), it was not until the report of UCHIDA et al.
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Diphtheria toxin conformational switching at acidic pH
The FEBS Journal, 2014O. Leka +5 more
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