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The Immunizing Value of Diphtheria Toxin-Anti-Toxin Mixture and of Diphtheria to Xoid
Public Health Reports (1896-1970), 1930 openaire +2 more sources
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Crystallization of diphtheria toxin
Journal of Molecular Biology, 1991Two new crystal forms (forms III and IV) have been grown of diphtheria toxin (DT), which kills susceptible cells by catalyzing the ADP-ribosylation of elongation factor 2, thereby stopping protein synthesis. Forms III and IV diffract to 2.3 A and 2.7 A resolution, respectively.
Seunghyon Choe +3 more
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On the formation of diphtheria toxin in saliva byC. diphtheriae
Antonie van Leeuwenhoek, 19531. The iron contents of a number of saliva samples were determined. The iron contents found varied from 0.10–0.61 γ per g of saliva, while in some cases the iron quantity present was so small that it could not be determined. 2. These iron contents are of the same quantitative order as the concentrations of this element in the various ...
L. Smith, A. Tasman
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Diphtheria Toxin and the Diphtheria-Toxin Receptor
2000The discovery of diphtheria toxin from culture medium of Corynehacterium diphtheriae was one of the greatest discoveries in medical history. Since this epoch-making change in medicine, diphtheria toxin has been studied, first to prevent disease and later to understand the pathogenic mechanism at the molecular level. A number of important discoveries in
K. D. Sharma, T. Umata, Eisuke Mekada
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Anaphylaxis to Diphtheria Toxin
The Journal of Immunology, 1932Abstract Previously reported experiments (1, 2, 3) on anaphylaxis apparently due to the toxin or toxoid antigen were made upon actively sensitized (antitoxic immune) animals. The results had indicated that while other diphtheria antigens participated to some extent, the major part of the anaphylaxis could be assigned to the toxin or ...
John Y Sugg +2 more
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2015
Diphtheria toxin (DT) is one of the most extensively studied bacterial toxins with intracellular action. It is produced by toxigenic strains of Corynebacterium diphtheriae and is responsible for the symptoms of diphtheria. The toxin was isolated in 1888. A vaccine was developed in 1923.
Daniel Gillet, Julien Barbier
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Diphtheria toxin (DT) is one of the most extensively studied bacterial toxins with intracellular action. It is produced by toxigenic strains of Corynebacterium diphtheriae and is responsible for the symptoms of diphtheria. The toxin was isolated in 1888. A vaccine was developed in 1923.
Daniel Gillet, Julien Barbier
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The crystal structure of diphtheria toxin
Nature, 1992The crystal structure of the diphtheria toxin dimer at 2.5 A resolution reveals a Y-shaped molecule of three domains. The catalytic domain, called fragment A, is of the alpha + beta type. Fragment B actually consists of two domains. The transmembrane domain consists of nine alpha-helices, two pairs of which are unusually apolar and may participate in ...
Gary Fujii +6 more
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Diphtheria Toxin Fusion Proteins
1998Two different approaches have been undertaken to develop targeted biomolecules for therapeutics. The first was the construction of immunotoxins consisting of monoclonal antibodies chemically linked through a disulfide bond to a plant or bacterial toxin or radionuclide.
James G. Krueger +4 more
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Diphtheria toxin-receptor interaction: A polyphosphate-insensitive diphtheria toxin-binding domain
Biochemical and Biophysical Research Communications, 1982Abstract Inositol hexaphosphate, and other polyphosphates, inhibit diphtheria toxin-mediated cytotoxicity by binding to the toxin at a highly cationic site called the P site and preventing toxin binding to cell surface receptors. The binding of diphtheria toxin to a solubilized cell surface glycoprotein (150,000 daltons) is also inhibited by these ...
Lisa L. Ross, Leon Eidels, David A. Hart
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