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The Effects of Inhibitors Upon Pore Formation by Diphtheria Toxin and Diphtheria Toxin T Domain
Journal of Membrane Biology, 1999The formation of pores by membrane-inserted diphtheria toxin is closely linked to the translocation of its catalytic chain across membranes. In this report a number of aromatic polyanionic molecules were identified that inhibit toxin-induced leakage of molecules from model membrane vesicles. One inhibitor, Cibacron blue, totally blocked pore formation.
Kelli Kachel, J.C. Sharpe, Erwin London
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Iron and Diphtheria Toxin Production
1975The extreme sensitivity of diphtheria toxin production to the iron concentration of the medium was clearly shown by Pappenheimer and Johnson [1]. Iron level of the medium, therefore, has to be carefully controlled whether diphtheria toxin is produced using a surface or a submerged culture.
S. S. Rao, S. V. Gadre
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Nature, 1968
ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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ULTRACENTRIFUGAL studies have shown that purified diphtheria toxin is a single protein with a molecular weight of 64,500 and an S20, w of 4.2 (ref. 1). In this communication, I report experiments with a sample of toxin that contains the 4.2 S molecule, and an unusual species with a higher sedimentation constant.
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The Diphtheria Toxin Structural Gene
1985While there was considerable indirect evidence that toxinogenesis in Corynebacterium diphtheria was related to lysogeny (FREEMAN 1951; FREEMAN AND MORSE 1952; GROMAN 1953 a, b, 1955; GROMAN and EATON 1955; HOLMES and BARKSDALE 1969), it was not until the report of UCHIDA et al.
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[11] Diphtheria toxin: Purification and properties
1988Publisher Summary This chapter describes the purification and properties of diphtheria toxin (DT). The chapter also discusses the purification of DT from toxin preparations obtained from commercial sources, and its subsequent fractionation into the various forms.
Joseph T. Barbieri+2 more
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Potent Diphtheria Toxin within the Cells of C. diphtheriae
Nature, 1954ALL the exotoxins except diphtheria toxin have been demonstrated within the bacterial cells in a very early stage of culture. So far as diphtheria toxin is concerned, it has been postulated, but never proved, that the exotoxin is formed within the cell.
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The Nature of Diphtheria Toxin
Journal of Infectious Diseases, 1928E. R. Main, Arthur Locke
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PURIFICATION OF DIPHTHERIA TOXIN AND DIPHTHERIA TOXOID
Acta Pathologica Microbiologica Scandinavica, 1947openaire +2 more sources