Results 31 to 40 of about 21,888 (230)

Combined Immediate‐Release and Extended‐Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja, Susanna Kääriäinen, Zsófia Lovró, Mia Lundblad, Kristina Drott, Elsa Lilienberg, Marica T. Engström, Karla Saukkonen, Mika Scheinin   +8 more
wiley   +1 more source

Workplace Drug Testing—Prevalence of Positive Test Results, Most Common Substances, and Importance of Medical Review

Drug Testing and Analysis, EarlyView.
Among 23,900 urine and oral fluid drug tests from Swedish workplaces, 4.6% tested positive for controlled substances. Cannabis, amphetamine, cocaine and benzodiazepines were most common. Many samples containing opiates, amphetamine or benzodiazepines were MRO verified as being due to medical prescriptions, while cannabis or cocaine were almost entirely
Anders Helander, Fredrik Sparring
wiley   +1 more source

Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility in murine heart failure

European Journal of Heart Failure, EarlyView.
Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility. Abstract Aims Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood.
Suzanne Nathalie Voorrips, Constantin Laurent Palm, Huitzilihuitl Saucedo‐Orozco, Belend Mahmoud, Elisabeth Marloes Schouten, Anna M. Feringa, Pablo I. Sanchez‐Aguilera, Kirsten T. Nijholt, Salva R. Yurista, Peter van der Meer, Herman H.W. Silljé, B. Daan Westenbrink   +11 more
wiley   +1 more source

Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study

Diagnostics, 2022
Albuminuria is a sensitive marker for renal dysfunction. Urinary dipstick tests are frequently used to screen for urinary abnormalities in the emergency department (ED).
Christian B. Nielsen, Henrik Birn, Frans Brandt, Jan D. Kampmann   +3 more
doaj   +1 more source

Albuminuria as a diagnostic criterion and a therapeutic target in heart failure and other cardiovascular disease

European Journal of Heart Failure, EarlyView.
The value of uACR. CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; uACR, urine albumin‐to‐creatinine ratio. Abstract The high disease burden and bidirectional relationship of chronic kidney disease (CKD), heart failure (HF) and other cardiovascular disease (CVD) necessitate the need for early ...
Biykem Bozkurt, Patrick Rossignol, Joseph A. Vassalotti   +2 more
wiley   +1 more source

The assessment of 24 24-h urine volume by measurement of urine specific gravity with dipstick in adults with nephrolithiasis

Advanced Biomedical Research, 2012
Background: Nephrolithiasis is a recurrent disease, and one of the most effective methods for prevention of stone recurrence is increasing the urine output (>2 L/day), but it is difficult to achieve it. The aim of this study was to evaluate the effect of
Mohamad Hatef Khorami, Rasool Hashemi, Reza Bagherian-Sararoudi, Merhrdad Mohammadi Sichani, Farhad Tadayon, Amir Abbas Shahdoost, Sayed Hamid Arezegar   +6 more
doaj   +1 more source

Recent Advances in Biosensor Technologies for Point-of-Care Urinalysis

Biosensors, 2022
Human urine samples are non-invasive, readily available, and contain several components that can provide useful indicators of the health status of patients.
Chuljin Hwang, Won-June Lee, Su Dong Kim, Sungjun Park, Joo Hee Kim   +4 more
doaj   +1 more source

Sedentary behavior during pregnancy and risk of pre‐eclampsia and/or gestational hypertension: A systematic review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Despite improvements in perinatal care, pre‐eclampsia remains a major cause of maternal and neonatal morbidity and mortality. Gestational hypertension and blood pressure are important intermediate endpoints for pre‐eclampsia. Sedentary behavior has emerged as an independent risk factor for chronic disease, regardless of physical ...
Lulu X. Pei, Shelby Marozoff
wiley   +1 more source

Fasting plasma glucose performs better than glycated hemoglobin and glycated albumin for diagnosing gestational diabetes

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Universal screening for gestational diabetes mellitus (GDM) using the oral glucose tolerance test (OGTT) has been recommended. In resource‐poor environments, OGTTs are only administered to high‐risk cases. In countries such as South Africa, where female obesity is common, this translates into high numbers of tests.
Lungile Khambule, Lawrence Chauke, Nigel J. Crowther, Jaya A. George   +3 more
wiley   +1 more source

The first pediatric study investigating the utility of a noninvasive urine‐based test for acute pancreatitis diagnosis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP) is a growing clinical concern with a wide spectrum of severity, from mild episodes to life‐threatening conditions. Traditional diagnostic methods primarily rely on serum amylase and lipase measurements, which are invasive and can be challenging in children.
Tamar Orgad, Isra Abu‐Rahma, David Rekhtman, Saar Hashavya, Peri Milman, Mordechai Slae, Zev Davidovics, Michael Wilschanski, Liron Birimberg‐Schwartz   +8 more
wiley   +1 more source