Results 31 to 40 of about 169,151 (235)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The dichotomy of diagnostics: exploring the value for consumers, clinicians and care pathways

npj Digital Medicine
Diagnostics play a crucial role in screening, detecting, and stratifying patients, yet can account for only 2–3% of healthcare spending. With advancements in wearable technology and direct-to-consumer testing, the market for consumer health continues to ...
Dylan Powell, Aiden Hannah
doaj   +1 more source

Assessment of physician preparedness for implementation of pathology-supported genetic testing: solution-driven post-COVID-19 survey

Frontiers in Genetics
IntroductionRapid advances in personalized medicine and direct-to-consumer genomic applications could increase the risk that physicians will apply genomic results inappropriately.
Elouise E. Kroon, Yolandi Swart, Chantelle J. Scott, Denise Scholtz, Daniel W. Olivier, Kelebogile E. Moremi, Kelebogile E. Moremi, Chantelle Venter, Maxine Waters, Sunday O. Oladejo, Craig J. Kinnear, Craig J. Kinnear, Etheresia Pretorius, Etheresia Pretorius, Kanshukan Rajaratnam, Kanshukan Rajaratnam, Desiree C. Petersen, Marlo Möller, Marlo Möller, Marlo Möller, Maritha J. Kotze   +20 more
doaj   +1 more source

How Can We Move Clinical Genomics Beyond the Hype? [PDF]

, 2011
Examines the debate over increased use of genetic testing, due in part to lax regulation, and its consequences: wasteful spending, patient harm, and health system challenges.
Michael L. Millenson
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The First Baby Born After Polygenic Embryo Screening

Voices in Bioethics, 2022
INTRODUCTION The possibility of using genetic technologies to engineer the perfect baby has long haunted the public imagination. While some techno-utopians have openly advocated for human genetic enhancement, many critics have warned that advances in ...
Kalina Kamenova, Hazar Haidar
doaj  

Developing the Intervention and Outcome Components of a Proposed Randomised Controlled trial (RCT) of a National Screening Programme for Open Angle Glaucoma (OAG) : Medical Research Council funded trial platform study (G0701759): Study protocol [PDF]

, 2008
Postprin
Azuara-Blanco, Augusto, Burr, Jennifer, Hernández, Rodolfo Andrés, Ramsay, Craig R, Vale, Luke David   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of interference to cable television due to mobile usage in the Digital Dividend [PDF]

, 2010
The start of use of mobile applications in the 800 MHz band, which forms part of the ‘Digital Dividend’, will cause interference to TV signals under certain conditions.
Arts, A.H.P., Bogaard, A., Fleurke, S.R., Pors, F.F., Robijns, J.J., Schiphorst, R., Slump, C.H., Smith, B., Wijninga, P.W.   +8 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source