Results 81 to 90 of about 15,752,675 (317)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Pharmaceutical and analytical evaluation of triphalaguggulkalpa tablets

Journal of Ayurveda and Integrative Medicine, 2011
Aim of the Study: Development of standardized, synergistic, safe and effective traditional herbal formulations with robust scientific evidence can offer faster and more economical alternatives for the treatment of disease.
Shreeram S Savarikar, Maneesha M Barbhind, Umakant K Halde, Alpana P Kulkarni   +3 more
doaj  

Development of the formulation and manufacturing process of lozenges with Ajania fruticulosa (Ledeb.) Poljak dry extract using the Quality by Design concept

Разработка и регистрация лекарственных средств
Introduction. This article presents the development of a technology for obtaining lozenges containing Ajania fruticulosa dry extract using the direct compression method.
A. M. Jakiyanov, C. I. Ridvanov, Zh. N. Issayev, G. T. Zhumashova, T. S. Bekezhanova, R. I. Kulmanbetov, Y. V. Talgayeva, Zh. Zh. Turuspayeva, Z. B. Sakipova, M. K. Suleimenov   +9 more
doaj   +1 more source

Formulation and evaluation of Nateglinide dispersible tablet by direct compression method

International Journal of Advances in Scientific Research, 2015
The study was carried to formulate and evaluate dispersible tablet dosage form obtaining Nateglinide.Nateglinideis adrugfor the treatment oftype 2 diabetes. The present study is an attempt to select best possible combination of diluents and disintegrates to formulate dispersible tablet of Nateglinide which disintegrates within few minutes thereby ...
Desu, Prasanna Kumar, Bonthagarala, Brahmaiah, Rao, Pasam Venkateswara   +2 more
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Orodispersible Tablets of Carbamazepine Prepared by Direct Compression Method Using 3 2 Full Factorial Design

, 2008
Orodispersible tablets of carbamazepine were prepared with a view to enhance patient compliance by direct compression method using 3² full factorial design. Crospovidone (2-10% w/w) was used as superdisintegrant and microcrystallinecellulose (0-30% w/w)
P. V. Swamy, S. Shahidulla, S. B. Shirsand, S. Hiremath, Younus Ali   +4 more
semanticscholar   +1 more source

Nimesulide dispersible tablets from'direct compression'method

, 2001
Direct compression, which is the method of choice in tablet manufacture to produce high quality of finished product, has been applied to prepare dispersible tablets of nimesulide. Nimesulide was subjected to preformulation studies to test the suitability
Srinivas, M., Udupa, N., Venugopal, K.R.
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