Results 41 to 50 of about 643,269 (259)

Conceptualizing and Measuring the Quality of Democracy: The Citizens’ Perspective

open access: yesPolitics and Governance, 2018
In recent years, several measurements of the quality of democracy have been developed (e.g. Democracy Barometer, Varieties of Democracy Project). These objective measurements focus on institutional and procedural characteristics of democracy.
Dieter Fuchs, Edeltraud Roller
doaj   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

FEATURES OF DIRECT DEMOCRACY IN SWITZERLAND: POLITICAL AND LEGAL ANALYSIS

open access: yesВісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології", 2022
The tools of realization of direct democracy in Switzerland are considered. The Swiss political system, levels of government and distribution of powers between institutions are analyzed.
Svitlana Denysiuk
doaj   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Fiduciary Voters? [PDF]

open access: yes, 2014
What does the majority owe the minority when issues are put to a vote? This question is central to direct democracy, where voters bypass the legislature and enact law directly. Some scholars have argued that voters in direct democracy bear fiduciary-like
Anundsson, Maria, Wändin, Ellenor
core   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Determinants of Direct Democracy [PDF]

open access: yes
This paper investigates on the demographic, economic, political and cultural determinants of direct democracy in 87 countries using an index of direct democracy.
Nadia Fiorino, Roberto Ricciuti
core   +3 more sources

Study of the Impact of Democracy and Corruption on Foreign Direct Investment in West and East Asian Countries [PDF]

open access: yesپژوهشهای اقتصادی, 2021
The purpose of this research is to study the effects of democracy and corruption on attracting foreign direct investment in West and East Asia. To do this, a dynamic panel model and generalized method of moments are employed over the period 2009-2018 ...
Hadiseh Taghizadeh Elyas Abad   +2 more
doaj  

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

open access: yesFEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa   +13 more
wiley   +1 more source

The Latvian direct democracy tools in a comparative European context

open access: yesOñati Socio-Legal Series, 2019
This article analyses and compares the legal tools of direct democracy in Latvia and other European countries. Based on comparison, the author draws concludes the shortcomings of the legal framework of direct democracy in the Constitution of the Republic
Fabio Ratto Trabucco
doaj   +1 more source

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