Results 41 to 50 of about 13,207 (299)
Does direct democracy increase civic virtues? A systematic literature review
Frontiers in Political ScienceDue to widespread citizen disenchantment with representative democracy, the introduction of direct-democratic institutions is often promoted as a promising remedy to overcome the current democratic crisis. Theorists of participatory democracy have argued
Laurent Bernhard
doaj +1 more source
Study of the Impact of Democracy and Corruption on Foreign Direct Investment in West and East Asian Countries [PDF]
پژوهشهای اقتصادی, 2021 The purpose of this research is to study the effects of democracy and corruption on attracting foreign direct investment in West and East Asia. To do this, a dynamic panel model and generalized method of moments are employed over the period 2009-2018 ...
Hadiseh Taghizadeh Elyas Abad +2 more
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Equality as the name of democracy - Bogdana Koljević: Democracy of contemporary French poststructuralism, Serbian State Publisher of Textbooks, Belgrade, 2018 [PDF]
Sociološki Pregled, 2019 This exceptional book for our public opens dilemmas about the potential of democracy as it is, an opinion which is frequently taken for granted or rejected here, in a rather arbitrary manner.
Bratina Boris R.
doaj
Deliberativa, diretta o partecipativa?
Quaderni di Sociologia, 2014 Representative democracy is currently challenged in all Western political systems. In Italy this challenge in recent years has been launched in a distinctive way by the Movimento Cinque Stelle (M5s, Five Star Movement).
Antonio Floridia, Rinaldo Vignati
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Direct Democracy in France and Poland. A Comparative Analysis
Annales Universitatis Mariae Curie-Skłodowska. Sectio K, PolitologiaThe aim of this article is to conduct a comparative analysis of direct democracy in France and Poland. In the research process, three research questions were formulated: 1) What is the tradition of direct democracy in France and Poland?; 2) What are the ...
Maria Marczewska-Rytko
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source