Results 161 to 170 of about 9,105,244 (296)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A direct effect of sulfatide against development of fibrosis. [PDF]

Metabol Open
Thea R, Buschard K.
europepmc   +1 more source

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog. [PDF]

Diabetes, 2023
Kraft G, Coate KC, Smith M, Farmer B, Scott M, Hastings J, Cherrington AD, Edgerton DS.   +7 more
europepmc   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Novel direct effect of CCR2 receptor on follicle activation process. [PDF]

Front Endocrinol (Lausanne)
Gamaleri Y, Ferman DS, Ting A, Dascal ER, Lomniczi A, Jaworski JP, Peluffo MC.   +6 more
europepmc   +1 more source

Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females. [PDF]

Int J Environ Res Public Health, 2022
Pan C, Zhao H, Du Q, Xu Y, Tian D, Xiao S, Wang H, Wei X, Wu C, Ruan Y, Zhao C, Tao G, Zheng W.   +12 more
europepmc   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Comparing the direct effect of lymphatic dynamic transport after lower-level laser therapy in healthy volunteers: a randomized controlled trial. [PDF]

Lasers Med Sci
Bae H, Jeon JY, Choi SH, Rhee MH, Kim YJ, Kong IJ, Eom JR, Yoon JA.   +7 more
europepmc   +1 more source

Spores of Trichoderma Strains over P. vulgaris Beans: Direct Effect on Insect Attacks and Indirect Effect on Agronomic Parameters. [PDF]

Insects, 2022
Rodríguez-González Á, Carro-Huerga G, Guerra M, Mayo-Prieto S, Porteous-Álvarez AJ, Lorenzana A, Campelo MP, Fernández-Marcos A, Casquero PA, Gutiérrez S.   +9 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source