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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Direct Effect: Convergence or Divergence? A Comparative Perspective
, 2002 Jans, J.H., Prinssen, J.M.
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Horizontal Direct Effect of Directives
SSRN Electronic Journal, 2015The concept of horizontal direct effect has gained prominence in recent years due to the importance it plays in lives of individuals who seek to enforce rights derived from the European Union (EU) law. Classic international law states that each State has the liberty to choose its “domestic law” as well as “international law”.
openaire +1 more source
2005
Abstract Soon after the case law of the Court of Justice on direct effect of Treaty provisions started to develop, the question was raised as to the possible direct effect of directives. As is often the case in any doctrinal controversy, there were opponents of direct effect of directives, as well as advocates thereof and those taking an
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Abstract Soon after the case law of the Court of Justice on direct effect of Treaty provisions started to develop, the question was raised as to the possible direct effect of directives. As is often the case in any doctrinal controversy, there were opponents of direct effect of directives, as well as advocates thereof and those taking an
openaire +1 more source
AIP Conference Proceedings, 2009
A hybrid data/modeling approach is applied to estimate global monthly distributions of total aerosol direct radiative effects and (anthropogenic) forcing. Despite strong regional variability, the annual global average impact of anthropogenic aerosol on climate is a weak cooling at about −0.2 W/m2 (as the radiative net‐flux change at the top of the ...
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A hybrid data/modeling approach is applied to estimate global monthly distributions of total aerosol direct radiative effects and (anthropogenic) forcing. Despite strong regional variability, the annual global average impact of anthropogenic aerosol on climate is a weak cooling at about −0.2 W/m2 (as the radiative net‐flux change at the top of the ...
openaire +2 more sources
ACM SIGGRAPH ASIA 2009 Sketches, 2009
One of the most common effects in the animated feature film Quantum Quest are the trails that fall behind and twisted around all photon characters, including the hero character Dave (Figure 1). The quantity of shots that required this effect warranted the development of a trailing system. In photography, when an image is taken with moving light sources
Pei-Zhi Huang +3 more
openaire +2 more sources
One of the most common effects in the animated feature film Quantum Quest are the trails that fall behind and twisted around all photon characters, including the hero character Dave (Figure 1). The quantity of shots that required this effect warranted the development of a trailing system. In photography, when an image is taken with moving light sources
Pei-Zhi Huang +3 more
openaire +2 more sources
The Directional Effect of Detonators
Journal of the Forensic Science Society, 1968Experiments have been conducted to determine the effectiveness of detonators in exploding gelignite placed short distances away. It was found that there was a marked directional effect along the axis of the detonator, probably due to propagation of a shock wave.
R C, Selkirk, D F, Nelson
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Direct myocardial effects of cocaine
Cardiovascular Research, 1993The aim was to determine whether cocaine has a direct effect on the myocardium which is independent of coronary vasospasm.Cocaine was introduced into the perfusate of the isolated rabbit ventricular septal preparation in the concentration range 10(-5) to 10(-3)M while holding coronary flow of oxygenated Krebs solution constant at 3.0 ml.min-1 by a ...
N C, Morcos, A, Fairhurst, W L, Henry
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