Results 61 to 70 of about 61,844 (169)

Comparison of Minimal Circular Balanced RMDs Constructed Through Rule I and II of Cyclic Shifts Method

open access: yesStats
The repeated measurement design (RMD) is a cost-effective research design commonly used in various fields. RMDs have several advantages; however, the carryover effect is a fundamental issue. Carryover effects typically serve as the primary source of bias
Muhammad Ejaz Malik   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The direct effect of World Trade Organization law in national legislation (approaches of the People's Republic of China and Russian Federation)

open access: yesУченые записки Казанского университета: Серия Гуманитарные науки, 2019
The principle provision of the Marrakesh Agreement of 1994 providing for harmonization of national laws and regulating external trade relations has been discussed in the paper.
N.E. Tyurina, Li Xu
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

'Clash of Titans' General Principles of EU Law: Balancing and Horizontal Direct Effect

open access: yesEuropean Papers, 2016
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(2), 643-652 | European Forum Insight of 8 August 2016 | (Table of Contents) I. The background of the case. - II. The Opinion of Advocate General Bot. - III.
Elena Gualco, Luísa Lourenço
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Spatial Spillover Effects of Digital Infrastructure on Food System Resilience: An Analysis Incorporating Threshold Effects and Spatial Decay Boundaries

open access: yesFoods
As an important carrier for the application of digital technologies, digital infrastructure plays a crucial role in promoting the digital transformation of the grain system and ensuring food security in the current era.
Yani Dong   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic variability and character association among biometrical traits in F2 generation of some Rice crosses [PDF]

open access: yesElectronic Journal of Plant Breeding, 2010
Twenty five F2 progenies derived from the crosses involving HYV s and quality rices were evaluated during kharif 2005.Eleven biometrical characters were studied for estimating phenotypic variance, genotypic variance, genotypic coefficient ofvariation ...
B.C. Nandeshwar*, S.Pal, B.K. Senapati and D.K. De
doaj  

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