Results 61 to 70 of about 8,286 (265)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Exchange Rates and Outward Foreign Direct Investment: US FDI in Emerging Economies [PDF]

open access: yes
The paper investigates the impact of exchange rates on US foreign direct investment (FDI) flows to a sample of 16 emerging market countries using annual panel data for the period 1990-2002.
Udomkerdmongkol, Manop   +2 more
core  

DETERMINANTS OF COCOA EXPORT EARNINGS IN NIGERIA (1980-2019) [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2022
This study investigated the determinants of cocoa export earnings in Nigeria between 1980 and 2019. Secondary data spanning between 1980 and 2019 were collected from reputable sources such as Food and Agriculture Organisation Statistical Database ...
Ahmed BUSARI   +3 more
doaj  

Direct Investment, Hysteresis, and Real Exchange Rate Volatility

open access: yesJournal of the Japanese and International Economies, 1996
Abstract Recent papers by Dixit and others have put forth the argument that real exchange shocks generate a condition of hysteresis in the export entry and exit prices, and that this wedge in prices explains the persistence in the U.S. current account deficit. This article shows that the critical hysteresis bounds for exports are altered dramatically
Nalin Kulatilaka, Bruce Kogut
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

FOREIGN DIRECT INVESTMENT AND EXCHANGE RATES: A CASE STUDY OF U.S. FDI IN EMERGING MARKET COUNTRIES [PDF]

open access: yes
This paper investigates the impact of exchange rates on US Foreign Direct Investment (FDI)inflows to a sample of 16 emerging market countries using panel data for the period 1990-2002.
Holger Görg   +2 more
core  

DETERMINANTS OF SHARIA FINTECH GROWTH IN INDONESIA: AN INTEGRATIVE ANALYSIS OF MACROECONOMIC INDICATORS AND MONETARY POLICY

open access: yesI-Finance
The purpose of this study is to determine the influence of macroeconomic factors (inflation and exchange rates) and monetary policy (interest rates and money supply) on the growth of Islamic fintech in Indonesia.
Muhammad Zaki As Shafi MT
doaj   +1 more source

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