Results 41 to 50 of about 4,482,608 (231)

Weed control by direct injection of plant protection products according to specific situations

Julius-Kühn-Archiv, 2016
Precision Farming in agriculture allows a site-specific management of the crop. The aim of plant protection is to apply plant protection products (PPP) according to the site specific requirements on the field.
Krebs, Mathias, Rautmann, Dirk, Nordmeyer, Henning   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Combustion and Emission Characteristics of Methanol–Diesel Dual Fuel Engine at Different Altitudes

Journal of Marine Science and Engineering
Currently, in the two technological approaches for using diesel pilot injection to ignite methanol and partially substituting diesel fuel with methanol, neither can fully achieve carbon neutrality in the context of internal combustion engines ...
Zhongcheng Wang, Zhu Jie, Xiaoyu Liu
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Flame Front Propagation in an Optical GDI Engine under Stoichiometric and Lean Burn Conditions

Energies, 2017
Lean fueling of spark ignited (SI) engines is a valid method for increasing efficiency and reducing nitric oxide (NOx) emissions. Gasoline direct injection (GDI) allows better fuel economy with respect to the port-fuel injection configuration, through ...
Santiago Martinez, Adrian Irimescu, Simona Silvia Merola, Pedro Lacava, Pedro Curto-Riso   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

High-Performance Hydrogen-Fueled Internal Combustion Engines: Feasibility Study and Optimization via 1D-CFD Modeling

Energies
Hydrogen-powered mobility is believed to be crucial in the future, as hydrogen constitutes a promising solution to make up for the non-programmable character of the renewable energy sources. In this context, the hydrogen-fueled internal combustion engine
Daniela A. Misul, Alex Scopelliti, Mirko Baratta   +2 more
doaj   +1 more source